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Persistent consolidation: a MALT-easer
  1. Garyfallia Perlepe1,
  2. Ourania S Kotsiou1,
  3. Eleni Karetsi1,
  4. Dimitris Papadopoulos2,
  5. Maria Ioannou1,
  6. Konstantinos I Gourgoulianis3
  1. 1 Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, Larissa, Greece
  2. 2 Respiratory, General University Hospital of Larisa, Larissa, Greece
  3. 3 Respiratory Medicine Department, University of Thessaly, Larissa, Greece
  1. Correspondence to Professor Ourania S Kotsiou, Department of Respiratory Medicine, University of Thessaly Faculty of Medicine, Larissa, Thessaly, Greece; raniakotsiou{at}gmail.com

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GP (pulmonary resident physician)

A 78-year-old man with a 40 pack-year history of smoking presented to the emergency department with 3 days of hemoptysis in a volume less than 20 mL/day, cough, low-grade fever, and 1-month history of dyspnoea on exertion. Previously, cefuroxime axetil had been administered with no response. He denied chest pain, wheezing, decreased appetite or weight loss. He experienced fatigue over the last 4 years. No occupational or environmental exposures were noted. His medical history included coronary disease and hypertension. He was found to have IgM lambda monoclonal gammopathy on serum protein electrophoresis with a serum M-protein concentration of 2.300 g/dL (normal 0.64–1.30 g/dL) 3 years ago, received no firm diagnosis. No myeloid or lymphoid neoplasia was detected in the bone marrow biopsy. He had undergone six chest CT examinations over the prior 4 years, demonstrating an irregularly shaped mass-like consolidation in the left lower lobe (figure 1A,B). He underwent a bronchoscopy 4 years earlier with negative bronchial cytology and cultures of bronchial washings for bacteria, fungi, and mycobacteria species. The last chest CT was 6 months ago revealed worsening of left lower lobe consolidation with distended bronchi (figure 1C,D). Unfortunately, he stated that he did not want any further investigation.

Figure 1

Serial chest CT imaging, haematological, bronchoscopic and histological findings of the patient. (A, B) Chest CT performed 4 years ago revealed an irregularly shaped mass-like consolidation in the left lower lobe. (C, D) Chest CT performed 6 months ago showed an enlarged left lower lobe consolidation with airways within the lesion. (E, F) The chest CT performed at admission showed a worsening of left lower lobe consolidation associated with bilateral ground-glass opacities and a left pleural effusion. (G) Serum protein electrophoresis showed elevated levels of gamma globulin. (H) Serum immunofixation electrophoresis showed a dense abnormal zone of restriction in the IgM lane and the lambda light chain lane. (I, J) The …

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Footnotes

  • GP and OSK contributed equally.

  • Contributors KIG, OSK, and GP conceived of the presented idea. OSK and GP wrote the manuscript. EK and DP performed the bronchoscopy. MI and KIG supervised the writing of the draft. All authors provided critical feedback and approved the final draft.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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