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ANT and AB are joint first authors.
DDC and SSH are joint senior authors.
Contributors SH, DC and AK devised the pathway. AT, JB, HJ, SB and AB revised the pathway, AT, SH and DC wrote the manuscript.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.