We developed a MRI protocol using transverse (T2) and longitudinal (T1) mapping sequences to characterise lung structural changes in preterm infants with bronchopulmonary dysplasia (BPD). We prospectively enrolled 61 infants to perform 3-Tesla MRI of the lung in quiet sleep. Statistical analysis was performed using logistic Group Lasso regression and logistic regression. Increased lung T2 relaxation time and decreased lung T1 relaxation time indicated BPD yielding an area under the curve (AUC) of 0.80. Results were confirmed in an independent study cohort (AUC 0.75) and mirrored by lung function testing, indicating the high potential for MRI in future BPD diagnostics.
Trial registration DRKS00004600.
- paediatric lung disaese
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Contributors BEW, HE and AH contributed to the conception and design. KF, HE, AWF, CH and OD contributed to acquiring data. KF, BEW, HB, SS, AP, LN, OD and AH contributed to analysis and interpretation. KF, BEW, HB, SS, AS, OE, FT, OD and AH contributed to the drafting of the manuscript for important intellectual content.
Funding NWG VH-NG-829 (Helmholtz Association), German Center for Lung Research (Federal Ministry of Science).
Competing interests None declared.
Patient consent for publication Not required.
Provenance and peer review Not commissioned; externally peer reviewed.