Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage

Marie-Louise Frémond; Marie Legendre; Michael Fayon; Annick Clement; Emilie Filhol-Blin; Nicolas Richard; Laura Berdah; Sylvie Roullaud; Gillian I Rice; Vincent Bondet; Darragh Duffy; Chiara Sileo; Hubert Ducou le Pointe; Hugues Begueret; Aurore Coulomb; Bénédicte Neven; Serge Amselem; Yanick Crow; Nadia Nathan

doi:10.1136/thoraxjnl-2019-213892

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Chest clinic

Case based discussion

Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage

Authors

Marie-Louise Frémond Laboratory of Neurogenetics and Neuroinflammation, Paris Descartes University, Sorbonne-Paris-Cité, Imagine Institute, Paris, France PubMed articles Google scholar articles
Marie Legendre Inserm UMR_S933, INSERM and Sorbonne Université, Paris, France Molecular Genetic Department, APHP, Trousseau Hospital, Sorbonne Université, Paris, France PubMed articles Google scholar articles
Michael Fayon Pediatric Pulmonology & CIC 1401, Cardio-Thoracic Research Center (U1045), Bordeaux University Hospital, Bordeaux, France PubMed articles Google scholar articles
Annick Clement Inserm UMR_S933, INSERM and Sorbonne Université, Paris, France Pediatric Pulmonology and Reference centre for rare lung diseases, AP-HP, Trousseau Hospital, Sorbonne University, Paris, France PubMed articles Google scholar articles
Emilie Filhol-Blin Inserm UMR_S933, INSERM and Sorbonne Université, Paris, France PubMed articles Google scholar articles
Nicolas Richard Pediatric Pulmonology and Reference centre for rare lung diseases, AP-HP, Trousseau Hospital, Sorbonne University, Paris, France PubMed articles Google scholar articles
Laura Berdah Pediatric Pulmonology and Reference centre for rare lung diseases, AP-HP, Trousseau Hospital, Sorbonne University, Paris, France PubMed articles Google scholar articles
Sylvie Roullaud Pediatric Department, CH Angouleme, Angouleme, Poitou-Charentes, France PubMed articles Google scholar articles
Gillian I Rice Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK PubMed articles Google scholar articles
Vincent Bondet Inserm 1223, and Laboratory of Dendritic Cell Immunobiology, Institut Pasteur, Paris, France PubMed articles Google scholar articles
Darragh Duffy Inserm 1223, and Laboratory of Dendritic Cell Immunobiology, Institut Pasteur, Paris, France PubMed articles Google scholar articles
Chiara Sileo Imaging Department, AP-HP, Trousseau Hospital, Sorbonne University, Paris, France PubMed articles Google scholar articles
Hubert Ducou le Pointe Imaging Department, AP-HP, Trousseau Hospital, Sorbonne University, Paris, France PubMed articles Google scholar articles
Hugues Begueret Pathology Department, Haut Lévêque University Hospital, Pessac, France PubMed articles Google scholar articles
Aurore Coulomb Pathology Department, APHP, Hôpital Trousseau, Sorbonne Université, Paris, France PubMed articles Google scholar articles
Bénédicte Neven Inserm UMR 1163, Laboratory of Immunogenetics of Pediatric Autoimmunity, Paris Descartes University, Sorbonne-Paris-Cité, Paris, France Paediatric Hematology-Immunology and Rheumatology Department, APHP, Necker Enfants Malades Hospital, Paris, France PubMed articles Google scholar articles
Serge Amselem Inserm UMR_S933, INSERM and Sorbonne Université, Paris, France PubMed articles Google scholar articles
Yanick Crow Laboratory of Neurogenetics and Neuroinflammation, Paris Descartes University, Sorbonne-Paris-Cité, Imagine Institute, Paris, France Centre for Genomic and Experimental Medicine, The University of Edinburgh MRC Institute of Genetics and Molecular Medicine, Edinburgh, UK PubMed articles Google scholar articles
Nadia Nathan Inserm UMR_S933, INSERM and Sorbonne Université, Paris, France Pediatric Pulmonology and Reference centre for rare lung diseases, AP-HP, Trousseau Hospital, Sorbonne University, Paris, France PubMed articles Google scholar articles

Correspondence to Dr Nadia Nathan, Pediatric Pulmonology and Reference centre for rare lung diseases, AP-HP, Trousseau Hospital, Sorbonne University, Paris 75012, France; nadia.nathan{at}aphp.fr

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Citation

Frémond M, Legendre M, Fayon M, et al

Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage

Thorax 2020;75:92-95.

Publication history

Received July 29, 2019
Revised October 1, 2019
Accepted October 4, 2019
First published October 30, 2019.

Online issue publication

December 13, 2019

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