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Original article
Genetic and observational evidence supports a causal role of sex hormones on the development of asthma
  1. Ryan Arathimos1,2,
  2. Raquel Granell1,
  3. Philip Haycock1,2,
  4. Rebecca C Richmond1,2,
  5. James Yarmolinsky1,2,
  6. Caroline L Relton1,2,
  7. Kate Tilling1,2
  1. 1 Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK
  2. 2 Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK
  1. Correspondence to Dr Ryan Arathimos, MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK; ryan.arathimos{at}bristol.ac.uk

Footnotes

  • Contributors RA, RG, KT and CLR were involved in project conceptualisation. RA and KT performed the formal analysis. RA, RG, RCR, JY and CLR were involved in methodology development. PH was involved in data curation and software provision. RA prepared the original draft. RG, PH, JY, RCR, CLR and KT reviewed and edited the manuscript.

  • Funding This work was supported by the MRC Integrative Epidemiology Unit and the University of Bristol (MC_UU_00011/5 and MC_UU_00011/3). The UK Medical Research Council and Wellcome (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). This research has been conducted using the UK Biobank Resource under Application No 15825.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethical approval for ALSPAC was obtained from the ALSPAC Ethics and Law Committee and the local research ethics committees. UK Biobank received ethical approval from the Research Ethics Committee (REC reference 11/NW/0382).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors RA, RG, KT and CLR were involved in project conceptualisation. RA and KT performed the formal analysis. RA, RG, RCR, JY and CLR were involved in methodology development. PH was involved in data curation and software provision. RA prepared the original draft. RG, PH, JY, RCR, CLR and KT reviewed and edited the manuscript.

  • Funding This work was supported by the MRC Integrative Epidemiology Unit and the University of Bristol (MC_UU_00011/5 and MC_UU_00011/3). The UK Medical Research Council and Wellcome (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). This research has been conducted using the UK Biobank Resource under Application No 15825.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Ethical approval for ALSPAC was obtained from the ALSPAC Ethics and Law Committee and the local research ethics committees. UK Biobank received ethical approval from the Research Ethics Committee (REC reference 11/NW/0382).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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