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Lung function in children with sickle cell disease from Central Africa
  1. Michele Arigliani1,
  2. Robert Kitenge2,3,
  3. Luigi Castriotta4,
  4. Pathy Ndjule5,
  5. Vincenzo Barbato6,
  6. Paola Cogo1,
  7. Leon Tshilolo2,3
  1. 1 Department of Medicine, University Hospital of Udine, Udine, Italy
  2. 2 Service de Pédiatrie, Centre Hospitalier Monkole, Kinshasa, Democratic Republic of the Congo
  3. 3 Centre de Formation et d’Appui Sanitaire (CEFA), Kinshasa, Democratic Republic of the Congo
  4. 4 Institute of Hygiene and Clinical Epidemiology, University Hospital of Udine, Udine, Italy
  5. 5 Mediprox Clinique, Kinshasa, Democratic Republic of the Congo
  6. 6 School of Medicine, University of Udine, Udine, Italy
  1. Correspondence to Dr Michele Arigliani,Department of Medicine, University Hospital of Udine, Udine, Italy; michelearigliani{at}gmail.com

Abstract

Lung function in patients with sickle cell anaemia (SCA) living in sub-Saharan Africa is largely unknown. Anthropometry and spirometry were cross-sectionally evaluated in patients with SCA (HbSS) aged 6–18 years and in schoolchildren from the Democratic Republic of the Congo. The Global Lung Initiative 2012 spirometry reference values were used. A total of 112 patients and 377 controls were included. Twenty-six per cent of patients with SCA had spirometry findings suggestive of a restrictive pattern and 41% had a FEV1 z-score <5th percentile. Wasting, increasing age and female sex were independently associated with increased risk of restrictive spirometry pattern in patients with SCA. Longitudinal studies could clarify the prognostic meaning of these findings.

  • respiratory measurement
  • paediatric physician
  • systemic disease and lungs
  • paediatric lung disaese
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Footnotes

  • Correction notice This article has been corrected since it was published Online First. There was an error to the percentage stated in the 'Discussion' section.

  • Contributors MA conceived the study, performed data collection, interpreted data and wrote the manuscript. RK and PN performed data collection and contributed to the manuscript. LC performed statistical analysis, interpreted data and contributed to the manuscript. VB contributed to statistical analysis, interpreted data and contributed to the manuscript. PC interpreted data and contributed to the manuscript. LT conceived the study, interpreted data and contributed to the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Guardian consent obtained.

  • Ethics approval The study was approved by the Monkole Hospital Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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