Background Panax ginseng (ginseng) is a therapeutic herb which might be beneficial in COPD. The study investigated if ginseng, compared with placebo, is effective and safe for people with moderate COPD.
Methods This multicentre, randomised, double-blind, placebo-controlled trial compared 24 weeks of ginseng capsules (100 mg twice daily) with placebo. Participants were followed up for a further 24 weeks. Participants were aged 40 years and over and had airflow limitation in the moderate (Global Initiative for Chronic Obstructive Lung Disease 2) COPD range. The coprimary endpoints were the St George’s Respiratory Questionnaire, the COPD Assessment Test and the Short Form Health Survey. Secondary outcomes included lung function, exacerbation rate and use of relief medication.
Findings 168 participants were randomised 1:1 from five centres in Australia and China. Baseline characteristics were balanced between groups. There were no significant differences between ginseng and placebo, with overall results improving in both groups. Ginseng seemed safe for, and well tolerated by, people with COPD.
Interpretation There was no significant difference in improvement in health-related quality of life (primary outcome) between the ginseng and placebo groups.
Trial registration number ACTRN12610000768099.
- chronic obstructive pulmonary disease
- randomised controlled trial
- quality of life
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LL and CCX are joint senior authors.
Contributors Conception: CX. Study design: CX, FT, CJW, LL, JLS, ALZ, HF, DW, DS. Data collection: JLS, LW, YC, YX, DL. Data analysis: CX, FT, CJW, LL, JLS, ALZ, HF, DW, CDC. Data interpretation: all authors. Writing and reviewing the manuscript: all authors. Final approval of the manuscript: all authors.
Funding The study was funded by a National Health and Medical Research Council (NHMRC) Project Grant (number 616609) and a National Institute of Complementary Medicine Australia Seeding Grant. The study was also supported by the National Natural Science Foundation of China (grant numbers 81573895 and 81673897) and Science and Technology Planning Project of Guangdong Province (grant number 2017A020213013). Ginsana SA provided the Ginsana capsules and placebo used in this study.
Competing interests None declared.
Patient consent for publication Obtained.
Ethics approval The protocol was approved by the ethics committee at each site: Austin Health Human Research Ethics Committee (approval number HREC/10/Austin/8, H2010/03892) and Guangdong Provincial Hospital of Traditional Chinese Medicine Institutional Ethics Committee (approval number B2013-171-01).
Provenance and peer review Not commissioned; externally peer reviewed.