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Original article
12-month randomised controlled trial of ginseng extract for moderate COPD
  1. Johannah Linda Shergis1,
  2. Francis Thien2,3,
  3. Christopher John Worsnop4,
  4. Lin Lin5,6,
  5. Anthony L Zhang1,
  6. Lei Wu5,6,
  7. Yuanbin Chen5,6,
  8. Yinji Xu5,6,
  9. David Langton3,7,
  10. Cliff Da Costa8,
  11. Harry Fong9,
  12. Darong Wu5,6,
  13. David Story1,
  14. Charlie C Xue1,6
  1. 1 School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia
  2. 2 Department of Respiratory Medicine, Eastern Health, Box Hill, Victoria, Australia
  3. 3 Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia
  4. 4 Department of Respiratory Medicine, Austin Health, Heidelberg, Victoria, Australia
  5. 5 The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China
  6. 6 Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China
  7. 7 Department of Thoracic Medicine, Frankston Hospital, Frankston, Victoria, Australia
  8. 8 School of Science, RMIT University, Melbourne, Victoria, Australia
  9. 9 Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  1. Correspondence to Distinguished Professor Charlie C Xue, School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia; charlie.xue{at}rmit.edu.au; Professor Lin Lin, The Second Clinical College of Guangzhou University of Chinese Medicine and the Guangdong Provincial Hospital of Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China; drlinlin620{at}163.com

Footnotes

  • LL and CCX are joint senior authors.

  • Contributors Conception: CX. Study design: CX, FT, CJW, LL, JLS, ALZ, HF, DW, DS. Data collection: JLS, LW, YC, YX, DL. Data analysis: CX, FT, CJW, LL, JLS, ALZ, HF, DW, CDC. Data interpretation: all authors. Writing and reviewing the manuscript: all authors. Final approval of the manuscript: all authors.

  • Funding The study was funded by a National Health and Medical Research Council (NHMRC) Project Grant (number 616609) and a National Institute of Complementary Medicine Australia Seeding Grant. The study was also supported by the National Natural Science Foundation of China (grant numbers 81573895 and 81673897) and Science and Technology Planning Project of Guangdong Province (grant number 2017A020213013). Ginsana SA provided the Ginsana capsules and placebo used in this study.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The protocol was approved by the ethics committee at each site: Austin Health Human Research Ethics Committee (approval number HREC/10/Austin/8, H2010/03892) and Guangdong Provincial Hospital of Traditional Chinese Medicine Institutional Ethics Committee (approval number B2013-171-01).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • LL and CCX are joint senior authors.

  • Contributors Conception: CX. Study design: CX, FT, CJW, LL, JLS, ALZ, HF, DW, DS. Data collection: JLS, LW, YC, YX, DL. Data analysis: CX, FT, CJW, LL, JLS, ALZ, HF, DW, CDC. Data interpretation: all authors. Writing and reviewing the manuscript: all authors. Final approval of the manuscript: all authors.

  • Funding The study was funded by a National Health and Medical Research Council (NHMRC) Project Grant (number 616609) and a National Institute of Complementary Medicine Australia Seeding Grant. The study was also supported by the National Natural Science Foundation of China (grant numbers 81573895 and 81673897) and Science and Technology Planning Project of Guangdong Province (grant number 2017A020213013). Ginsana SA provided the Ginsana capsules and placebo used in this study.

  • Competing interests None declared.

  • Patient consent for publication Obtained.

  • Ethics approval The protocol was approved by the ethics committee at each site: Austin Health Human Research Ethics Committee (approval number HREC/10/Austin/8, H2010/03892) and Guangdong Provincial Hospital of Traditional Chinese Medicine Institutional Ethics Committee (approval number B2013-171-01).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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