Systemic inflammation and metabolic disorders are among the mechanisms linking obstructive sleep apnoea (OSA) and cardiovascular disease (CVD). In 109 patients with severe OSA and no overt CVD, biomarkers of inflammation (C reactive protein, interleukin-6, tumour necrosis factor-α and its receptors, adiponectin, leptin and P-selectin), glucose and lipid metabolism, and N-terminal pro-brain natriuretic peptide, were measured before and after 2 months of treatment with a mandibular advancement device (MAD) (n=55) or a sham device (n=54). MAD reduced the Apnoea–Hypopnoea Index (p<0.001) but had no effect on circulating biomarkers compared with the sham device, despite high treatment adherence (6.6 hour/night).
Trial registration number NCT01426607.
- obstructive sleep apnoea syndrome
- mandibular advancement device
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Contributors SR, J-LP, BV, RA, FC-G, BF, FG, SL, CM, NM, VB, X-LN, AP, PP, RT, WT and FG were substantially involved in the design of the study and critical revision of the paper for important intellectual content. SR, FG, J-LP, BV and WT were substantially involved in drafting the article. All authors were substantially involved in data acquisition, data analysis and/or interpretation of data. They critically revised the article for important intellectual content.
Funding This study was supported by a grant from the French Ministry of Health (PHRC-I 2010-06). J-LP and RT are supported by the French National Research Agency in the framework of the ‘Investissements d’avenir’ programme (ANR-15-IDEX-02).
Competing interests None declared.
Patient consent Obtained.
Ethics approval Comité de Protection des Personnes, Ouest II, Angers, France; No. 2010/14.
Provenance and peer review Not commissioned; externally peer reviewed.
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