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Primary lung cancer in patients with previous malignancies: a nationwide study
  1. Onno M Mets1,
  2. Cornelia M Schaefer-Prokop2,3,
  3. Pim A de Jong1
  1. 1 Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
  2. 2 Department of Radiology, Meander Medical Center, Amersfoort, The Netherlands
  3. 3 Diagnostic Image Analysis Group, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
  1. Correspondence to Onno M Mets, Department of Radiology, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CX, The Netherlands; metsonno{at}


Overall survival of patients with cancer continues to increase and so they receive more frequent CT imaging, making oncological patients a growing population that effectively receives lung cancer screening in the course of daily practice. However, it is currently uncertain how early lung cancer detection in this subgroup of patients should be optimally managed. We describe the relationship between primary lung cancer and prior malignancies in a nationwide cohort, in an attempt to identify possible areas of improvement in nodule management. We found that a substantial number of subjects with lung cancer suffered from a prior malignancy; however, with the exception of otorhinolaryngeal malignancies, they did not show a high absolute risk for lung cancer. Future research should provide more data on how to handle this subgroup of patients in clinical and screening setting.

  • lung cancer
  • Imaging/CT MRI etc
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  • Contributors OMM: study planning, data gathering/analysis, drafting of the manuscript, final approval. CMS-P: study planning, drafting of the manuscript, final approval. PAdJ (guarantor): study planning, drafting of the manuscript, final approval.

  • Funding This study was supported by a grant from the Dutch Cancer Foundation (KUN 2013-6110).

  • Competing interests OMM received revenue from Aidence (Veye Chest software) as expert panel member.

  • Patient consent Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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