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Original article
Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis
  1. Jilles M Fermont1,2,
  2. Katya L Masconi2,
  3. Magnus T Jensen3,4,
  4. Renata Ferrari5,
  5. Valéria A P Di Lorenzo6,
  6. Jacob M Marott4,
  7. Philipp Schuetz7,
  8. Henrik Watz8,
  9. Benjamin Waschki8,
  10. Hana Müllerova9,
  11. Michael I Polkey10,
  12. Ian B Wilkinson1,
  13. Angela M Wood2
  1. 1 Department of Medicine, Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK
  2. 2 Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
  3. 3 Department of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark
  4. 4 Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen, Denmark
  5. 5 Division of Pulmonology, Department of Internal Medicine, Botucatu Medical School, Univ Estadual Paulista, UNESP, Botucatu, Brazil
  6. 6 Department of Physiotherapy, Federal University of Sao Carlos (UFSCar), São Carlos/São Paulo, Brazil
  7. 7 Internal Medicine and Emergency Medicine, Kantonsspital Aarau, Univertsity of Basel, Aarau, Switzerland
  8. 8 LungenClinic Grosshansorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany
  9. 9 Worldwide Epidemiology, GlaxoSmithKline R&D, Uxbridge, UK
  10. 10 Respiratory Muscle Laboratory, Royal Brompton Hospital, London, UK
  1. Correspondence to Mr. Jilles M Fermont, Department of Medicine, Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge CB1 8RN, UK; jmf88{at}medschl.cam.ac.uk

Footnotes

  • Contributors JMF and AMW designed the study. JMF, MTJ, RF, VAPDL, JLM, PS, HW, BW and HM contributed to the data collection. JMF and KLM extracted the data. JMF conducted the analysis and produced the results figures and tables. AMW and KLM provided statistical support. JMF wrote the initial draft of the manuscript. KLM, MIP, IBW and AMW contributed to the writing of the manuscript. All coauthors read and commented on the manuscript.

  • Funding This study was funded by GlaxoSmithKline (RG79358).

  • Disclaimer The views and opinions expressed are those of the authors and do not necessarily reflect those of the University of Cambridge. The funder of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.

  • Competing interests GlaxoSmithKline, a consortium partner, funded JMF. HM is an employee of GSK and own shares and stock options of GSK Plc. MIP received grants from GSK outside the submitted work. IBW received grants from GSK during the conduct of the study and outside the submitted work.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Most of the data used in the meta-analysis are publicly available. Where data were unpublished and obtained from the corresponding author, summary statistics can be requested.

  • Patient consent for publication Not required.

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Footnotes

  • Contributors JMF and AMW designed the study. JMF, MTJ, RF, VAPDL, JLM, PS, HW, BW and HM contributed to the data collection. JMF and KLM extracted the data. JMF conducted the analysis and produced the results figures and tables. AMW and KLM provided statistical support. JMF wrote the initial draft of the manuscript. KLM, MIP, IBW and AMW contributed to the writing of the manuscript. All coauthors read and commented on the manuscript.

  • Funding This study was funded by GlaxoSmithKline (RG79358).

  • Disclaimer The views and opinions expressed are those of the authors and do not necessarily reflect those of the University of Cambridge. The funder of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report.

  • Competing interests GlaxoSmithKline, a consortium partner, funded JMF. HM is an employee of GSK and own shares and stock options of GSK Plc. MIP received grants from GSK outside the submitted work. IBW received grants from GSK during the conduct of the study and outside the submitted work.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Most of the data used in the meta-analysis are publicly available. Where data were unpublished and obtained from the corresponding author, summary statistics can be requested.

  • Patient consent for publication Not required.

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