Purpose Malignant pleural mesothelioma (MPM) has a high symptom burden and poor survival. Evidence from other cancer types suggests some benefit in health-related quality of life (HRQoL) with early specialist palliative care (SPC) integrated with oncological services, but the certainty of evidence is low.
Methods We performed a multicentre, randomised, parallel group controlled trial comparing early referral to SPC versus standard care across 19 hospital sites in the UK and one large site in Western Australia. Participants had newly diagnosed MPM; main carers were additionally recruited. Intervention: review by SPC within 3 weeks of allocation and every 4 weeks throughout the study. HRQoL was assessed at baseline and every 4 weeks with the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30. Primary outcome: change in EORTC C30 Global Health Status 12 weeks after randomisation.
Results Between April 2014 and October 2016, 174 participants were randomised. There was no significant between group difference in HRQoL score at 12 weeks (mean difference 1.8 (95% CI −4.9 to 8.5; p=0.59)). HRQoL did not differ at 24 weeks (mean difference −2.0 (95% CI −8.6 to 4.6; p=0.54)). There was no difference in depression/anxiety scores at 12 weeks or 24 weeks. In carers, there was no difference in HRQoL or mood at 12 weeks or 24 weeks, although there was a consistent preference for care, favouring the intervention arm.
Conclusion There is no role for routine referral to SPC soon after diagnosis of MPM for patients who are cared for in centres with good access to SPC when required.
Trial registration number ISRCTN18955704.
- palliative care
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Contributors FB: study conception, study design, data collection, analysis, interpretation and writing. SG: study design and data collection. IL: study design, data collection, analysis, interpretation and literature search. LM: study design, study conduct and data collection. CF: study design and conduct. CQ and SG: statistical analysis. LC, NH, SK, BY, DC, PC, EF, JW, CP, AB, CM, AT and LS: recruitment and data collection. NM: study design, data collection, analysis and interpretation. KF: study design, analysis and interpretation. AC: study design, data collection, analysis, interpretation and writing.
Funding British Lung Foundation and Australian Communities Grant.
Disclaimer The British Lung Foundation and the Australian Communities Foundation had no role in the study design, data collection, data analysis, data interpretation or writing of the report.
Competing interests None declared.
Patient consent Not required.
Ethics approval Ethical approval for this study was granted by the National Research Ethics Service Committee, London (Hampstead, UK), reference 12/LO/0078.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.
Collaborators RESPECT-Meso investigators: Andrew Bateman, Melissa Dobson, Richard Hopgood, Samuel King, Angela Morgan, Stephen Morris, Alice Mortlock, Neal Navani, Anna Nowak, Michael Peake, Mark Roberts, Lynne Squibb, Paul Taylor.
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