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Original article
Vitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials
  1. David A Jolliffe1,
  2. Lauren Greenberg1,
  3. Richard L Hooper1,
  4. Carolien Mathyssen2,
  5. Rachida Rafiq3,
  6. Renate T de Jongh3,
  7. Carlos A Camargo4,
  8. Christopher J Griffiths1,5,
  9. Wim Janssens2,
  10. Adrian R Martineau1,5
  1. 1 Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
  2. 2 Department of Respiratory Medicine, Katholieke Universiteit, Leuven, Belgium
  3. 3 Department of Internal Medicine and Endocrinology, VU University Medical Center, Amsterdam, The Netherlands
  4. 4 Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, UK
  5. 5 Asthma UK Centre for Applied Research, Blizard Institute, Queen Mary University of London, London, UK
  1. Correspondence to Professor Adrian R Martineau, The Centre for Primary Care and Public Health, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AB, UK ; a.martineau{at}qmul.ac.uk

Footnotes

  • WJ and ARM contributed equally.

  • Contributors ARM led the funding application, with input from RLH, CAC and CJG who were coapplicants. ARM, DAJ and WJ assessed eligibility of studies for inclusion. ARM, DAJ, CM, RR, RTdJ and WJ were all directly involved in the acquisition of data for the work. RLH designed statistical analyses in consultation with authors contributing individual patient data. Statistical analyses were done by DAJ, LG and RLH. ARM wrote the first draft of the report. All authors revised it critically for important intellectual content, gave final approval of the version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work were appropriately investigated and resolved.

  • Funding This research was supported by a grant from National Institute for Health Research (NIHR) under its Health Technology Assessment (HTA) Programme (Reference Number 13/03/25 to ARM).

  • Disclaimer The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR or the Department of Health.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement A partial dataset, incorporating patient level data from RCTs for which the relevant permission for data sharing have been obtained, is available from the corresponding author at a.martineau@qmul.ac.uk.

  • Patient consent for publication Not required.

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Footnotes

  • WJ and ARM contributed equally.

  • Contributors ARM led the funding application, with input from RLH, CAC and CJG who were coapplicants. ARM, DAJ and WJ assessed eligibility of studies for inclusion. ARM, DAJ, CM, RR, RTdJ and WJ were all directly involved in the acquisition of data for the work. RLH designed statistical analyses in consultation with authors contributing individual patient data. Statistical analyses were done by DAJ, LG and RLH. ARM wrote the first draft of the report. All authors revised it critically for important intellectual content, gave final approval of the version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work were appropriately investigated and resolved.

  • Funding This research was supported by a grant from National Institute for Health Research (NIHR) under its Health Technology Assessment (HTA) Programme (Reference Number 13/03/25 to ARM).

  • Disclaimer The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR or the Department of Health.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement A partial dataset, incorporating patient level data from RCTs for which the relevant permission for data sharing have been obtained, is available from the corresponding author at a.martineau@qmul.ac.uk.

  • Patient consent for publication Not required.

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