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NOTCH3 contributes to rhinovirus-induced goblet cell hyperplasia in COPD airway epithelial cells
  1. Yaxun Jing1,
  2. Joao Antonio Gimenes2,
  3. Rahul Mishra1,
  4. Duc Pham1,
  5. Adam T Comstock1,
  6. Daohai Yu3,
  7. Umadevi Sajjan1,2,4
  1. 1 Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, USA
  2. 2 Department of Thoracic Surgery and Medicine, Temple University, Philadelphia, Pennsylvania, USA
  3. 3 Department of Clinical Sciences, Temple University, Philadelphia, Pennsylvania, USA
  4. 4 Department of Physiology, Temple University, Philadelphia, Pennsylvania, USA
  1. Correspondence to Professor Umadevi Sajjan, Departments of Physiology, and Thoracic Medicine and Surgery, Center for Inflammation, Translational and Clinical Lung Research, Lewis Katz Medical School, Temple University, Philadelphia PA 19140, USA; uma.sajjan{at}temple.edu

Footnotes

  • Contributors YJ and JAG designed and performed experiments. RM, DP and ATM provided technical assistance with cell culture and animal work. DY performed statistical analysis and wrote description of statistical analysis. US conceived the idea for the manuscript, helped to design appropriate experiments and prepared the manuscript.

  • Funding This work was supported by National Institutes of Health grants HL897720, AT004793 and AT007620 to US.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Institutional regulatory board, University of Michigan, Ann Arbor, Michigan.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors YJ and JAG designed and performed experiments. RM, DP and ATM provided technical assistance with cell culture and animal work. DY performed statistical analysis and wrote description of statistical analysis. US conceived the idea for the manuscript, helped to design appropriate experiments and prepared the manuscript.

  • Funding This work was supported by National Institutes of Health grants HL897720, AT004793 and AT007620 to US.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Institutional regulatory board, University of Michigan, Ann Arbor, Michigan.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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