Multi-plex reverse transcription polymerase chain reaction (RT-PCR) testing has enabled the rapid, accurate diagnosis of viral lower respiratory tract infections in clinical practice. However, the impact of RT-PCR testing for respiratory viruses (VRP) on outcomes in adults is unclear. We retrospectively reviewed the electronic medical records of all patients (at least 18 years old) who had VRP testing (Biofire Film Array) performed at 4 community hospitals in the northeastern USA between November 1, 2014, and June 15, 2015. Viruses detected by VRP included adenovirus, coronavirus, human metapneumovirus, influenza A and B, parainfluenza and respiratory syncytial virus. Patients with positive cultures for acute bacterial or mycoplasma infections were excluded as were those with chest x-ray or chest CT findings consistent with pneumonia. Of the 475 in the study group, 214 (45%) had positive VRP while 261 (55%) had negative VRP. Of those with positive VRP, 147 (69%) were treated with antibiotics. Of those with negative VRP, 145 (56%) received antibiotics. The average duration of antibiotics after VRP testing was 3.7 days in those with positive VRP (n=147) and 4.3 days in those with negative VRP (n=145). The average hospital length of stay (LOS) following VRP was 4.8 days in those with positive VRP (n=208) and 4.5 days in patients with negative VRP (n=257). There were 25 (12%) readmissions within 30 days of discharge for inpatients with positive VRP and 40 (16%) readmissions within 30 days of discharge for inpatients with negative VRP. Positive VRP was associated with a higher frequency of antibiotic therapy but a shorter duration of antibiotics. Positive VRP was associated with a lower frequency of hospital readmission within 30 days of discharge. Average hospital LOS was similar for positive VRP and negative VRP patient groups. Prospective study is warranted to further our understanding of the impact of VRP testing on clinical outcomes in adults with lower respiratory tract infections.