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Interstitial lung abnormalities and self-reported health and functional status
  1. Gisli Thor Axelsson1,2,
  2. Rachel K Putman3,
  3. Tetsuro Araki4,5,
  4. Sigurdur Sigurdsson1,
  5. Elias Freyr Gudmundsson1,
  6. Gudny Eiriksdottir1,
  7. Thor Aspelund1,2,
  8. Ezra R Miller3,
  9. Lenore J Launer6,
  10. Tamara B Harris6,
  11. Hiroto Hatabu4,5,
  12. Vilmundur Gudnason1,2,
  13. Gary Matt Hunninghake3,5,
  14. Gunnar Gudmundsson2,7
  1. 1 Icelandic Heart Association, Kopavogur, Iceland
  2. 2 Faculty of Medicine, University of Iceland, Reykjavik, Iceland
  3. 3 Pulmonary and Critical Care Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
  4. 4 Department of Radiology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
  5. 5 Center for Pulmonary Functional Imaging, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
  6. 6 Intramural Research Program, National Institute on Aging, Bethesda, Maryland, USA
  7. 7 Department of Respiratory Medicine, Landspitali University Hospital, Reykjavik, Iceland
  1. Correspondence to Dr Gunnar Gudmundsson, Department of Respiratory Medicine, Landspitali University Hospital, Reykjavik IS-108, Iceland; ggudmund{at}


We investigated the association between interstitial lung abnormalities (ILA) and self-reported measures of health and functional status in 5764 participants from the Age, Gene/Environment Susceptibility-Reykjavik study. The associations of ILA to activities of daily living (ADLs), general health status and physical activity were explored using logistic regression models. Participants with ILA were less likely to be independent in ADLs (OR 0.70; 95% CI 0.55 to 0.90) to have good or better self-reported health (OR 0.66; 95% CI 0.52 to 0.82) and to participate in physical activity (OR 0.72; CI 0.56 to 0.91). The results demonstrate ILA’s association with worsening self-reported health and functional status.

  • idiopathic pulmonary fibrosis
  • interstitial fibrosis
  • imaging/ct mri etc
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  • GTA and RKP contributed equally.

  • Contributors Study design: HH, VG, GMH and GG. Acquisition, analysis or interpretation of the data: GTA, RKP, TAs, SS, EFG, GE, TAr, HH, VG, GMH and GG. Statistical analysis: GTA, RKP, TAs and GMH. Obtained funding: VG, GMH and GG. All authors contributed to the critical revision of the manuscript for important intellectual content.

  • Funding RKP is supported by a National Institutes of Health (NIH) grant (T32 HL007633). GG is supported by a project grant from the Icelandic Research Fund (141513-051) and from the Landspitali Scientific Fund (A-2015-030, A-2016-023). The Age, Gene/ Environment Susceptibility-Reykjavik study was supported by a National Institute on Aging (NIA) grant (27120120022C), two NIH contracts (N01-AG-1-2100 and HHSN27120120022C), the NIA Intramural Research Program, Hjartavernd (the Icelandic Heart Association) and the Althingi (the Icelandic Parliament). VG is supported by an NIA grant (27120120022C) and an Icelandic Research Fund project grant (141513-051). GMH is supported by NIH grants (P01 HL114501, R01 HL111024, R01 HL135142, RO1 HL130974) and a project grant from the Icelandic Research Fund (141513-051).

  • Competing interests None declared.

  • Ethics approval National Bioethics Committee in Iceland (VSN: 00-063) and National Institute on Ageing Intramural Institutional Review Board.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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