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Chronic obstructive pulmonary disease and the risk of 12 cardiovascular diseases: a population-based study using UK primary care data
  1. Ann D Morgan1,
  2. Kieran J Rothnie1,2,
  3. Krishnan Bhaskaran2,
  4. Liam Smeeth2,
  5. Jennifer K Quint1,2
  1. 1 Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, UK
  2. 2 Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
  1. Correspondence to Ann D Morgan, National Heart and Lung Institute, Imperial College London, Manresa Road, London SW3 6LR, UK; a.morgan15{at}


Risks for cardiovascular diseases (CVDs) other than myocardial infarction and stroke in the general COPD population are not well quantified. We used a matched cohort study design and Cox regression to estimate relative risks for 12 separate CVDs in a large population-based cohort of patients with COPD over a 12-year period. Associations between COPD and individual CVDs were heterogeneous, with the highest relative risks observed for heart failure and diseases of the arterial circulation (in excess of 2.5 for those aged 64–75 years). Relative risks declined with increasing age but for most CVD outcomes remained unchanged over the study period.

  • copd epidemiology
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  • Contributors LS and JKQ served as principal investigators and conceived and designed the study; ADM conducted the data analysis and drafted the manuscript; KJR and KB provided statistical support and assisted with the data analysis; all co-authors read and commented on earlier versions of the manuscript.

  • Funding This work was conducted as part of a research degree funded by The British Lung Foundation (RG14-15). LS is supported by a Wellcome Senior Clinical Fellowship. KB holds a Sir Henry Dale fellowship jointly funded by the Wellcome Trust and the Royal Society.

  • Competing interests None declared.

  • Ethics approval The protocol for this research was approved by the Independent Scientific Advisory Committee (ISAC) for MHRA Database Research (protocol no. 15_114R) and the approved protocol was made available to the journal and reviewers during peer review. Generic ethical approval for observational research using the CPRD with approval from ISAC has been granted by a Health Research Authority (HRA) Research Ethics Committee (East Midlands—Derby, REC reference no. 05/MRE04/87). The study also has the approval of the London School of Hygiene and Tropical Medicine (LSHTM) Ethics Committee (No. 7611).

  • Provenance and peer review Not commissioned; externally peer reviewed.

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