Cochrane Reviews summarise best evidence and should inform guidelines. We assessed the use of Cochrane Reviews in the UK guidelines for paediatric respiratory disease. We found 21 guidelines which made 1025 recommendations, of which 96 could be informed by a Cochrane Review. In 38/96 recommendations (40%), some or all of the relevant Cochrane Reviews were not cited. We linked recommendations to 140 Cochrane Reviews. In 37/140 (26%) cases, the guideline recommendation did not fully agree with the Cochrane Review. Guideline developers may fail to use Cochrane Reviews or may make recommendations which are not in line with best evidence.
- Asthma Guidelines
- Paediatric Lung Disaese
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Author note The protocol is available for this study at http://eprints.nottingham.ac.uk/3031/ (part 1) and http://eprints.nottingham.ac.uk/3032/ (part 2).
Contributors The study was conceived by ARS, with development by APP and TC. Final study design was achieved by discussion of all authors. Data collection and analysis: TC, APP and SJS. Data analysis, statistics and programming: APP. Final manuscript written and approved by all authors.
Funding This work did not receive specific funding. APP was funded by a NIHR Doctoral Research Fellowship (DRF-2009-02-112), and is currently funded by a NIHR ACL post. DAH receives financial support from the MRC North West Hub in Trial Methodological Research: MR/K025635/1. The funders and sponsor had no involvement in the decision to publish, or the contents of the publication. This report presents independent research funded by the National Institute for Health Research.
Competing interests All authors have completed the Unified Competing Interests form at http://www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: no support from any organisation for the submitted work; no financial relationships with any organisations that might have an interest in the submitted work in the previous 3 years, no other relationships or activities that could appear to have influenced the submitted work. Professor Smyth reports personal fees from Vertex, personal fees from Gilead, personal fees from Roche, personal fees from PTC Therapeutics, outside the submitted work. In addition, Professor Smyth has a patent Alkyl Quinolones as Biomarkers of Pseudomonas aeruginosa Infection and Uses Thereof issued.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement The raw data and computer code underlying this study to fully reproduce all the statistics and figures reported are available as a downloadable online supplementary file on GitHub https://github.com/andrewprayle/Do-guidelines-for-treating-chest-disease-in-children-use-Cochrane-reviews-effectively.
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