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Changes in dynamic lung mechanics after lung volume reduction coil treatment of severe emphysema
  1. Demosthenes Makris1,2,
  2. Sylvie Leroy2,
  3. Johana Pradelli2,
  4. Jonathan Benzaquen2,
  5. Hervé Guenard3,
  6. Jeanne-Marie Perotin4,
  7. Spyros Zakynthinos5,
  8. Epaminondas Zakynthinos1,
  9. Gaëtan Deslee4,
  10. Charles Hugo Marquette2
  1. 1ICU, University Hospital Larissa, University of Thessaly, Biopolis Larissa, Greece
  2. 2Université Côte d’Azur, CHU de Nice, FHU Oncoage, Service de Pneumologie, Nice, France
  3. 3Service d’Exploration Fonctionnelle, CHU Victor Segalen, Bordeaux II, Bordeaux, France
  4. 4Service de Pneumologie, INSERM U903, Hôpital Universitaire de Reims, Reims, France
  5. 5ICU, Evaggelismos University Hospital, Athens University, Athens, Greece
  1. Correspondence to Professor Charles Hugo Marquette, Service de Pneumologie, Hospital Pasteur, University Côte d’Azur, FHU OncoAge, Côte d’Azur University, Nice 06000, France; marquette.c{at}


We assessed the relationships between changes in lung compliance, lung volumes and dynamic hyperinflation in patients with emphysema who underwent bronchoscopic treatment with nitinol coils (coil treatment) (n=11) or received usual care (UC) (n=11). Compared with UC, coil treatment resulted in decreased dynamic lung compliance (CLdyn) (p=0.03) and increased endurance time (p=0.010). The change in CLdyn was associated with significant improvement in FEV1 and FVC, with reduction in residual volume and intrinsic positive end-expiratory pressure, and with increased inspiratory capacity at rest/and at exercise. The increase in end-expiratory lung volume (EELV) during exercise (EELVdyn-ch=EELVisotime EELVrest) demonstrated significant attenuation after coil treatment (p=0.02).

  • emphysema
  • lung volume reduction
  • exercise capacity
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  • Contributors DM had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: DM, SL, HG, GD and CHM. Acquisition of data: DM, SL, JP, JB and CHM. Analysis and interpretation of data: DM, SZ and EZ. Drafting of the manuscript: DM and CHM. Critical revision of the manuscript for important intellectual content: DM, SL, JB, JMP, GD and CHM. Statistical analysis: DM. Study supervision: CHM.

  • Funding This study was sponsored by the UNICE and the RESPIR foundations.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Sud Mediterranée V - EC 13.051.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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