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Change in FVC and survival in chronic fibrotic hypersensitivity pneumonitis
  1. Andrea Gimenez,
  2. Karin Storrer,
  3. Lilian Kuranishi,
  4. Maria Raquel Soares,
  5. Rimarcs Gomes Ferreira,
  6. Carlos A C Pereira
  1. Interstitial Lung Diseases Program, Federal University of São Paulo, São Paulo, Brazil
  1. Correspondence to Dr Andrea Gimenez, Interstitial Lung Diseases Program, Federal University of São Paulo, R. Sena Madureira, 1500 - Vila Clementino, São Paulo 04023-062, Brazil; andrea.gimenez{at}


The predictive value of the decline in FVC by ≥10% on survival in patients with fibrotic hypersensitivity pneumonitis is unknown. Of 112 patients included, 66 (59%) had surgical lung biopsies. Patients with ≥10% decline in predicted FVC after 6–12 months had a significantly increased risk of all-cause mortality (median survival 53 months, 95% CI 37 to 69 vs 139 months, 95% CI 66 to 212 months, p=0.007). On multivariate analysis remained associated with increasing mortality: decline in FVC by ≥10% (HR 4.13, 95% CI 1.96 to 8.70, p=0.005), lower FVC% (HR 1.03, 95% CI 1.01 to 1.05, p=0.003) and with decreasing mortality improvement with antigen avoidance (HR 0.18, 95% CI 0.04 to 0.77, p=0.021).

  • hypersensitivity pneumonitis
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  • Contributors MRS contributed to the planning of the work. LK and KS contributed to conduct of the work.

  • Competing interests None declared.

  • Ethics approval Ethics committee in research from the Federal University of São Paulo.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Author note Andrea gimenez acted in data collection, data analysis, bibliographical survey and wrote this paper. Carlos AC Pereira Advisor of doctoral thesis. He performed the statistical review and helped in the making of paper. Rimarcs Gomes ferreira has reviewed all the material anatomopatologico and helped in the diagnosis of HP.

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