Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study

Zhang Wang; Richa Singh; Bruce E Miller; Ruth Tal-Singer; Stephanie Van Horn; Lynn Tomsho; Alexander Mackay; James P Allinson; Adam J Webb; Anthony J Brookes; Leena M George; Bethan Barker; Umme Kolsum; Louise E Donnelly; Kylie Belchamber; Peter J Barnes; Dave Singh; Christopher E Brightling; Gavin C Donaldson; Jadwiga A Wedzicha; James R Brown

doi:10.1136/thoraxjnl-2017-210741

Article info

Chronic obstructive pulmonary disease

Original article

Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study

Free

Authors

Zhang Wang Computational Biology, Target Sciences, Research and Development (R&D), GlaxoSmithKline, Collegeville, Pennsylvania, USA PubMed articles Google scholar articles
Richa Singh National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Bruce E Miller Respiratory Therapy Area Unit, R&D, GlaxoSmithKline, King of Prussia, Pennsylvania, USA PubMed articles Google scholar articles
Ruth Tal-Singer Respiratory Therapy Area Unit, R&D, GlaxoSmithKline, King of Prussia, Pennsylvania, USA PubMed articles Google scholar articles
Stephanie Van Horn Target and Platform Validation, Target Sciences, GlaxoSmithKline, Collegeville, Pennsylvania, USA PubMed articles Google scholar articles
Lynn Tomsho Target and Platform Validation, Target Sciences, GlaxoSmithKline, Collegeville, Pennsylvania, USA PubMed articles Google scholar articles
Alexander Mackay National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
James P Allinson National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Adam J Webb Department of Genetics and Genome Biology, University of Leicester, Leicester, UK PubMed articles Google scholar articles
Anthony J Brookes Department of Genetics and Genome Biology, University of Leicester, Leicester, UK PubMed articles Google scholar articles
Leena M George Institute for Lung Health, University of Leicester, Leicester, UK PubMed articles Google scholar articles
Bethan Barker Institute for Lung Health, University of Leicester, Leicester, UK PubMed articles Google scholar articles
Umme Kolsum Centre for Respiratory Medicine and Allergy, University of Manchester and University Hospital of South Manchester, Manchester, UK PubMed articles Google scholar articles
Louise E Donnelly National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Kylie Belchamber National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Peter J Barnes National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Dave Singh Centre for Respiratory Medicine and Allergy, University of Manchester and University Hospital of South Manchester, Manchester, UK PubMed articles Google scholar articles
Christopher E Brightling Institute for Lung Health, University of Leicester, Leicester, UK PubMed articles Google scholar articles
Gavin C Donaldson National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Jadwiga A Wedzicha National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
James R Brown Computational Biology, Target Sciences, Research and Development (R&D), GlaxoSmithKline, Collegeville, Pennsylvania, USA PubMed articles Google scholar articles
on behalf of COPDMAP
Google scholar articles

Correspondence to Dr James R Brown, Computational Biology, Target Sciences, Research and Development (R&D), GlaxoSmithKline (GSK), Collegeville, PA 19426, USA; james.r.brown{at}gsk.com

View Full Text

Citation

Wang Z, Singh R, Miller BE on behalf of COPDMAP, et al

Sputum microbiome temporal variability and dysbiosis in chronic obstructive pulmonary disease exacerbations: an analysis of the COPDMAP study

Thorax 2018;73:331-338.

Publication history

Received July 7, 2017
Revised November 2, 2017
Accepted November 27, 2017
First published December 21, 2017.

Online issue publication

March 19, 2018

Article Versions

Previous version (21 December 2017).
You are viewing the most recent version of this article.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Main menu

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password