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Association between asthma and lung function in adolescents born very preterm: results of the EPIPAGE cohort study
  1. Alice Hadchouel1,2,3,4,
  2. Jessica Rousseau5,
  3. Jean-Christophe Rozé6,7,
  4. Catherine Arnaud8,9,10,
  5. Adèle Bellino11,
  6. Laure Couderc12,
  7. Stéphane Marret13,14,
  8. Marie Mittaine15,
  9. Didier Pinquier12,
  10. Marie Verstraete16,
  11. Pierre-Yves Ancel3,4,5,
  12. Christophe Delacourt1,2,3,4
  13. the EPIPAGEADO study group
    1. 1 Service de Pneumologie et d’Allergologie Pédiatriques, AP-HP, Hôpital Universitaire Necker-Enfants Malades, Paris, France
    2. 2 U955, Equipe 4, INSERM, Créteil, France
    3. 3 Obstetrical, Perinatal, and Pediatric Epidemiology Team, Epidemiology and Biostatistics Sorbonne Paris Cité Research Center (U1153), INSERM, Paris, France
    4. 4 Paris Descartes University, Paris, France
    5. 5 Clinical Research Unit, Center for Clinical Investigation, P1419Cochin Broca Hôtel-Dieu, APHP, Paris, France
    6. 6 Service de Médecine Néonatale, CHU de Nantes, Nantes, France
    7. 7 CIC004, CHU de Nantes, Nantes, France
    8. 8 UMR1027, INSERM, Toulouse, France
    9. 9 Université Paul Sabatier, Toulouse, France
    10. 10 Unité d’épidémiologie clinique, CHU Purpan, Toulouse, France
    11. 11 Unité de Recherche Clinique Cochin-Necker, AP-HP, Paris, France
    12. 12 Unité de Pneumologie et Allergologie pédiatriques & CRCM mixte, Pédiatrie Médicale, CHU Charles Nicolle, Rouen, France
    13. 13 U1245, équipe Neovasc, handicap périnatal neurologique et neuro-protection, INSERM, Rouen, France
    14. 14 IRIB , Faculté de médecine, Université de Rouen, Rouen, France
    15. 15 Unité de Pneumologie et Allergologie pédiatriques, CHU Purpan, Toulouse, France
    16. 16 CRCM Enfants, CHU de Nantes, Nantes, France
    1. Correspondence to Dr Alice Hadchouel, Service de Pneumologie et Allergologie Pédiatriques, Hôpital Necker-Enfants Malades, Paris 75015, France; alice.hadchouel-duverge{at}


    Prematurity and bronchopulmonary dysplasia (BPD) affect long-term lung function. We studied the respiratory outcome of adolescents born very preterm and controls from the Etude EPIdémiologique sur les Petits Ages Gestationnels cohort and analysed their current lung function in relation to asthma symptoms (categorised in three age groups) from birth. In models including BPD, asthma at each age and confounding factors in the preterm group, BPD and preschool wheeze were the only independent variables associated with FEV1. Preschool wheeze is an independent factor associated with FEV1 impairment in adolescents born very preterm. These results highlight the need for optimal management of early respiratory symptoms in preterm-born infants.

    Trial registration number Results, NCT01424553.

    • paediatric asthma
    • paediatric lung disaese

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    • Contributors Study concept and design: AH, CD, CA, J-CR, SM and P-YA. Data acquisition: CD, MM, MV, LC, AB and the members of the EPIPAGEADO study group. Analysis and interpretation of data: AH, CD, P-YA and JR. Drafting the article: AH, CD, P-YA and JR. Critical revision of the manuscript for important intellectual content: AH, CD, P-YA. CA, J-CR, SM, MM, MV, LC, JR and the members of the EPIPAGEADO study group. Final approval of the version to be published: AH, CD, P-YA, JR, AB, CA, J-CR, SM, MM, MV, LC, and the members of the EPIPAGEADO study group. AH and P-YA had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

    • Funding The EPIPAGEADO study was sponsored by the Assistance Publique-Hôpitaux de Paris (Département de la Recherche Clinique et de Développement). The study was funded by a grant from the Programme Hospitalier de Recherche Clinique (PHRC) 2010 (Ministère de la Santé, N°AOM P100117). AH was funded by l’Agence Nationale de la Recherche (ANR-12-BSV1-0004-01).

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval Local ethics committee: CPP Île-de-France VI.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Collaborators The EPIPAGEADO study group includes: François Brémont; Maryline Delattre; Monique Kaminski; Géraldine Labouret; Muriel Lebourgeois; Christophe Marguet; Marie-Carole Paruit; Laetitia Peaudecerf; Catherine Tardif.

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