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The effect of early growth patterns and lung function on the development of childhood asthma: a population based study

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  • Contributors MC and LD designed the study with contributions from and the approval of all the other co-authors. CJK obtained the data on early childhood growth patterns and prepared the dataset. MC performed all statistical analyses. MV, IKR and VWVJ contributed as experts on child growth, while HTdD, JS and JCdJ contributed as experts on child respiratory health. MC interpreted the data and wrote the first draft of the manuscript. LD directed the study, interpreted the data, and critically reviewed all versions of the manuscript. All authors reviewed the manuscript for important intellectual content, and carefully read and approved the final version.

  • Funding The Generation R Study is made possible by financial support from the Erasmus Medical Centre, Rotterdam, Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development. Dr Liesbeth Duijts received additional funding from the European Union’s Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL) (ALPHABET project (no. 696295; 2017), ZonMW The Netherlands (no. 529051014; 2017)). The study was supported by the Netherlands Organization for Health Research and Development (VIDI 016.136.361), a European Research Council Consolidator Grant (ERC-2014-CoG-648916), funding from the European Union’s Seventh Framework Programme under grant agreement no. 289346 (EarlyNutrition), and funding from the European Union’s Horizon 2020 research and innovation programme under grant agreements no. 733206 (LifeCycle) and no. 633595 (DynaHEALTH). Dr Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128). The researchers are independent from the funders.

  • Disclaimer The study sponsors had no role in the study design, data collection, data analysis, interpretation of data, and preparation, review or approval of the manuscript.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Ethics approval Medical Ethical Committee of the Erasmus Medical Centre, Rotterdam.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Author note The Generation R Study is conducted by the Erasmus Medical Centre in close collaboration with the School of Law and the Faculty of Social Sciences at Erasmus University, Rotterdam, the Municipal Health Service, Rotterdam area, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (Star-MDC), Rotterdam.

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Footnotes

  • Contributors MC and LD designed the study with contributions from and the approval of all the other co-authors. CJK obtained the data on early childhood growth patterns and prepared the dataset. MC performed all statistical analyses. MV, IKR and VWVJ contributed as experts on child growth, while HTdD, JS and JCdJ contributed as experts on child respiratory health. MC interpreted the data and wrote the first draft of the manuscript. LD directed the study, interpreted the data, and critically reviewed all versions of the manuscript. All authors reviewed the manuscript for important intellectual content, and carefully read and approved the final version.

  • Funding The Generation R Study is made possible by financial support from the Erasmus Medical Centre, Rotterdam, Erasmus University Rotterdam and the Netherlands Organization for Health Research and Development. Dr Liesbeth Duijts received additional funding from the European Union’s Horizon 2020 co-funded programme ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL) (ALPHABET project (no. 696295; 2017), ZonMW The Netherlands (no. 529051014; 2017)). The study was supported by the Netherlands Organization for Health Research and Development (VIDI 016.136.361), a European Research Council Consolidator Grant (ERC-2014-CoG-648916), funding from the European Union’s Seventh Framework Programme under grant agreement no. 289346 (EarlyNutrition), and funding from the European Union’s Horizon 2020 research and innovation programme under grant agreements no. 733206 (LifeCycle) and no. 633595 (DynaHEALTH). Dr Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (CD12/00563 and MS16/00128). The researchers are independent from the funders.

  • Disclaimer The study sponsors had no role in the study design, data collection, data analysis, interpretation of data, and preparation, review or approval of the manuscript.

  • Competing interests None declared.

  • Patient consent Parental/guardian consent obtained.

  • Ethics approval Medical Ethical Committee of the Erasmus Medical Centre, Rotterdam.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Author note The Generation R Study is conducted by the Erasmus Medical Centre in close collaboration with the School of Law and the Faculty of Social Sciences at Erasmus University, Rotterdam, the Municipal Health Service, Rotterdam area, and the Stichting Trombosedienst and Artsenlaboratorium Rijnmond (Star-MDC), Rotterdam.

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