In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.
- Cystic Fibrosis
- Exhaled Airway Markers
- Respiratory Measurement
- Imaging/CT MRI
Statistics from Altmetric.com
Contributors SV and EV: designed the study and drafted the manuscript. DS, BI, CWE and JdM: performed data analysis at the Brussels site. GGK, WZ, AM and CT: performed data analysis at the Sydney site. SV, CT, GGK, WV and EV: supervised the study and reviewed the final manuscript version.
Funding This project was supported by the Fund for Scientific Research-Flanders (FWO-Vlaanderen, Belgium).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.