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Respiratory infection
Original Article
Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway

Authors

  • Vinciane Saint-Criq INSERM U1152, Laboratoire d’Excellence Inflamex, Département Hospitalo-Universtaire FIRE (Fibrosis, Inflammation and Remodeling), Université Paris Diderot, Sorbonne Paris Cité, Hopital Bichat - Claude-Bernard, Paris, France PubMed articlesGoogle scholar articles
  • Bérengère Villeret INSERM U1152, Laboratoire d’Excellence Inflamex, Département Hospitalo-Universtaire FIRE (Fibrosis, Inflammation and Remodeling), Université Paris Diderot, Sorbonne Paris Cité, Hopital Bichat - Claude-Bernard, Paris, France PubMed articlesGoogle scholar articles
  • Fabien Bastaert INSERM U1152, Laboratoire d’Excellence Inflamex, Département Hospitalo-Universtaire FIRE (Fibrosis, Inflammation and Remodeling), Université Paris Diderot, Sorbonne Paris Cité, Hopital Bichat - Claude-Bernard, Paris, France PubMed articlesGoogle scholar articles
  • Saadé Kheir INSERM U1152, Laboratoire d’Excellence Inflamex, Département Hospitalo-Universtaire FIRE (Fibrosis, Inflammation and Remodeling), Université Paris Diderot, Sorbonne Paris Cité, Hopital Bichat - Claude-Bernard, Paris, France PubMed articlesGoogle scholar articles
  • Aurélie Hatton INSERM U1151, Faculté de Médecine, site Necker, Université Paris Descartes, Paris, France PubMed articlesGoogle scholar articles
  • Aurélie Cazes INSERM U1152, Laboratoire d’Excellence Inflamex, Département Hospitalo-Universtaire FIRE (Fibrosis, Inflammation and Remodeling), Université Paris Diderot, Sorbonne Paris Cité, Hopital Bichat - Claude-Bernard, Paris, France PubMed articlesGoogle scholar articles
  • Zhou Xing McMaster Immunology Research Centre, McMaster University, Hamilton, Canada PubMed articlesGoogle scholar articles
  • Isabelle Sermet-Gaudelus INSERM U1151, Faculté de Médecine, site Necker, Université Paris Descartes, Paris, France PubMed articlesGoogle scholar articles
  • Ignacio Garcia-Verdugo INSERM U1152, Laboratoire d’Excellence Inflamex, Département Hospitalo-Universtaire FIRE (Fibrosis, Inflammation and Remodeling), Université Paris Diderot, Sorbonne Paris Cité, Hopital Bichat - Claude-Bernard, Paris, France PubMed articlesGoogle scholar articles
  • Aleksander Edelman INSERM U1151, Faculté de Médecine, site Necker, Université Paris Descartes, Paris, France PubMed articlesGoogle scholar articles
  • Jean-Michel Sallenave INSERM U1152, Laboratoire d’Excellence Inflamex, Département Hospitalo-Universtaire FIRE (Fibrosis, Inflammation and Remodeling), Université Paris Diderot, Sorbonne Paris Cité, Hopital Bichat - Claude-Bernard, Paris, France PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Jean-Michel Sallenave; jean-michel.sallenave{at}inserm.fr
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Citation

Saint-Criq V, Villeret B, Bastaert F, et al
Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway
Thorax 2018;73:49-61.

Publication history

  • Received April 4, 2017
  • Revised July 11, 2017
  • Accepted July 17, 2017
  • First published August 8, 2017.
Online issue publication 
September 01, 2022

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/