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Bodduluri and the COPDGene Investigators investigated the relationship between CT derived local lung expansion and contraction (Jacobian determinant) and functional outcome in COPD (see page 409). The deformation field between the two lung volumes, mapping local volume change with respiration, was associated with health related quality of life, exercise capacity and mortality. Will this be part of lung functioning testing going forward? Shiraz only knows.
The ‘Cristal’ Maze
John and colleagues are not using a crystal ball to try and see the future but genome-wide data (see page 400). They enrolled over 4000 adults to investigate if the genetic regions that impact on cross-sectional lung function were important in determining longitudinal lung function. In particular, they focussed on 26 known genetic regions and analysed the effect on longitudinal changes in FEV1 and FEV1/FVC. Although these regions had a strong relationship with baseline lung function, there was no effect on longitudinal lung function…predicting the future is more difficult than you think as the editorial highlights (see page …
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