Article Text

Download PDFPDF

Original article
Coexistence of OSA may compensate for sleep related reduction in neural respiratory drive in patients with COPD
  1. Bai-Ting He1,
  2. Gan Lu2,
  3. Si-Chang Xiao1,
  4. Rui Chen3,
  5. Joerg Steier4,
  6. John Moxham4,
  7. Michael I Polkey5,
  8. Yuan-Ming Luo1
  1. 1State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China
  2. 2Jiangsu Provincial Official Hospital, Nanjing, China
  3. 3Department of Respiratory Medicine, Second Affiliated Hospital of Soochow University, Suzhou, China
  4. 4Faculty of Life Sciences and Medicine, King's College London, London, UK
  5. 5NIHR Respiratory Biomedical Research Unit, The Royal Brompton and Harefield NHS Foundation Trust and Imperial College, Royal Brompton Hospital, London, UK
  1. Correspondence to Professor YM Luo, State Key Laboratory of Respiratory Disease, 151 Yanjiang Road, Guangzhou 510120, China; yuanmingluo9431{at}yahoo.co.uk or Dr R Chen, Department of Respiratory Medicine, Second Affiliated Hospital of Soochow University, Suzhou, China; chenruigood{at}126.com

Abstract

Background The mechanisms underlying sleep-related hypoventilation in patients with coexisting COPD and obstructive sleep apnoea (OSA), an overlap syndrome, are incompletely understood. We compared neural respiratory drive expressed as diaphragm electromyogram (EMGdi) and ventilation during stage 2 sleep in patients with COPD alone and patients with overlap syndrome.

Methods EMGdi and airflow were recorded during full polysomnography in 14 healthy subjects, 14 patients with OSA and 39 consecutive patients with COPD. The ratio of tidal volume to EMGdi was measured to indirectly assess upper airway resistance.

Results Thirty-five patients with COPD, 12 healthy subjects and 14 patients with OSA completed the study. Of 35 patients with COPD, 19 had COPD alone (FEV1 38.5%±16.3%) whereas 16 had an overlap syndrome (FEV1 47.5±16.2%, AHI 20.5±14.1 events/hour). Ventilation (VE) was lower during stage 2 sleep than wakefulness in both patients with COPD alone (8.6±2.0 to 6.5±1.5 L/min, p<0.001) and those with overlap syndrome (8.3±2.0 to 6.1±1.8 L/min). Neural respiratory drive from wakefulness to sleep decreased significantly for patients with COPD alone (29.5±13.3% to 23.0±8.9% of maximal, p<0.01) but it changed little in those with overlap syndrome. The ratio of tidal volume to EMGdi was unchanged from wakefulness to sleep in patients with COPD alone and healthy subjects but was significantly reduced in patients with OSA or overlap syndrome (p<0.05).

Conclusions Stage 2 sleep-related hypoventilation in COPD alone is due to reduction of neural respiratory drive, but in overlap syndrome it is due to increased upper airway resistance.

  • COPD ÀÜ Mechanisms
  • Respiratory Muscles
  • Sleep apnoea

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

View Full Text

Statistics from Altmetric.com

Footnotes

  • BH, GL and SX contributed equally to this work.

  • Contributors Conception and design: BH, GL, SX, JS, JM, MP, YL; analysis and interpretation: BH, GL, SX, RC; drafting the manuscript for important intellectual content: BH, GL, SX, RC, JS, JM, MP, YL.

  • Funding The work was supported by National Natural Science Foundation of China (NSFC No. 81120108001 and 81270143). Professor Polkey's contribution to this project was supported by the NIHR Respiratory Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London UK, who part funded his salary.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval The Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles