Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Eric W F W Alton; Jeffery M Beekman; A Christopher Boyd; June Brand; Marianne S Carlon; Mary M Connolly; Mario Chan; Sinead Conlon; Heather E Davidson; Jane C Davies; Lee A Davies; Johanna F Dekkers; Ann Doherty; Sabrina Gea-Sorli; Deborah R Gill; Uta Griesenbach; Mamoru Hasegawa; Tracy E Higgins; Takashi Hironaka; Laura Hyndman; Gerry McLachlan; Makoto Inoue; Stephen C Hyde; J Alastair Innes; Toby M Maher; Caroline Moran; Cuixiang Meng; Michael C Paul-Smith; Ian A Pringle; Kamila M Pytel; Andrea Rodriguez-Martinez; Alexander C Schmidt; Barbara J Stevenson; Stephanie G Sumner-Jones; Richard Toshner; Shu Tsugumine; Marguerite W Wasowicz; Jie Zhu

doi:10.1136/thoraxjnl-2016-208406

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Cystic fibrosis

Original article

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

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Eric W F W Alton Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Jeffery M Beekman Department of Pediatric Pulmonology, Laboratory of Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands PubMed articles Google scholar articles
A Christopher Boyd Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
June Brand Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK Lung Pathology Unit, Department of Airway Disease Infection, NHLI, Imperial College London, London, UK PubMed articles Google scholar articles
Marianne S Carlon Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Brussels, Belgium PubMed articles Google scholar articles
Mary M Connolly UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Gene Medicine Research Group, NDCLS, John Radcliffe Hospital, Oxford, UK PubMed articles Google scholar articles
Mario Chan Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Sinead Conlon Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Heather E Davidson UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Jane C Davies Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Lee A Davies UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Gene Medicine Research Group, NDCLS, John Radcliffe Hospital, Oxford, UK PubMed articles Google scholar articles
Johanna F Dekkers Department of Pediatric Pulmonology, Laboratory of Translational Immunology, Wilhelmina Children's Hospital, University Medical Centre, Utrecht, The Netherlands PubMed articles Google scholar articles
Ann Doherty UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Sabrina Gea-Sorli Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Deborah R Gill UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Gene Medicine Research Group, NDCLS, John Radcliffe Hospital, Oxford, UK PubMed articles Google scholar articles
Uta Griesenbach Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Mamoru Hasegawa ID Pharme Co. Ltd. (DNAVEC Center), Tsukuba, Japan PubMed articles Google scholar articles
Tracy E Higgins Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Takashi Hironaka ID Pharme Co. Ltd. (DNAVEC Center), Tsukuba, Japan PubMed articles Google scholar articles
Laura Hyndman UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Gerry McLachlan UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Roslin Institute & R(D)SVS, University of Edinburgh, Midlothian, UK PubMed articles Google scholar articles
Makoto Inoue ID Pharme Co. Ltd. (DNAVEC Center), Tsukuba, Japan PubMed articles Google scholar articles
Stephen C Hyde UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Gene Medicine Research Group, NDCLS, John Radcliffe Hospital, Oxford, UK PubMed articles Google scholar articles
J Alastair Innes UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Toby M Maher Fibrosis Research Group, Inflammation, Repair & Development Section, National Heart and Lung Institute, Sir Alexander Fleming Building, Imperial College, London, UK PubMed articles Google scholar articles
Caroline Moran Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Cuixiang Meng Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Michael C Paul-Smith Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Ian A Pringle UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Gene Medicine Research Group, NDCLS, John Radcliffe Hospital, Oxford, UK PubMed articles Google scholar articles
Kamila M Pytel Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Andrea Rodriguez-Martinez Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Alexander C Schmidt Ave Leopold Wiener, Brussels, Belgium PubMed articles Google scholar articles
Barbara J Stevenson UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Stephanie G Sumner-Jones UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK Gene Medicine Research Group, NDCLS, John Radcliffe Hospital, Oxford, UK PubMed articles Google scholar articles
Richard Toshner Fibrosis Research Group, Inflammation, Repair & Development Section, National Heart and Lung Institute, Sir Alexander Fleming Building, Imperial College, London, UK PubMed articles Google scholar articles
Shu Tsugumine ID Pharme Co. Ltd. (DNAVEC Center), Tsukuba, Japan PubMed articles Google scholar articles
Marguerite W Wasowicz Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London, UK UK Cystic Fibrosis Gene Therapy Consortium, Oxford, UK PubMed articles Google scholar articles
Jie Zhu Lung Pathology Unit, Department of Airway Disease Infection, NHLI, Imperial College London, London, UK PubMed articles Google scholar articles

Correspondence to Professor Uta Griesenbach, Department of Gene Therapy, National Heart and Lung Institute, Imperial College London, London SW3 6LR, UK; u.griesenbach{at}imperial.ac.uk Dr Chris Boyd, The Centre for Genomic and Experimental medicine, IGMM, University of Edinburgh, Edinburgh EH4 2XU, UK; Chris.Boyd{at}ed.ac.uk. Professor Deborah Gill, Gene Medicine Research Group, NDCLS, John Radcliffe Hospital, Oxford OX3 9DU, UK; Deborah.gill{at}ndcls.ox.ac.uk

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Citation

Alton EWFW, Beekman JM, Boyd AC, et al

Preparation for a first-in-man lentivirus trial in patients with cystic fibrosis

Thorax 2017;72:137-147.

Publication history

Received January 27, 2016
Revised June 21, 2016
Accepted June 28, 2016
First published November 16, 2016.

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September 01, 2022

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