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Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts
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Authors

  • Peter J Castaldi Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA Division of General Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA PubMed articlesGoogle scholar articles
  • Marta Benet ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Universitat Pompeu Fabra (UPF), Barcelona, Spain CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Hans Petersen COPD Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA PubMed articlesGoogle scholar articles
  • Nicholas Rafaels Center for Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • James Finigan Department of Medicine, National Jewish Health, Denver, Colorado, USA PubMed articlesGoogle scholar articles
  • Matteo Paoletti Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy PubMed articlesGoogle scholar articles
  • H Marike Boezen Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
  • Judith M Vonk Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
  • Russell Bowler Department of Medicine, National Jewish Health, Denver, Colorado, USA PubMed articlesGoogle scholar articles
  • Massimo Pistolesi Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy PubMed articlesGoogle scholar articles
  • Milo A Puhan Epidemiology, Biostatistics & Prevention Institute, University of Zurich, Zurich, Switzerland PubMed articlesGoogle scholar articles
  • Josep Anto ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain Universitat Pompeu Fabra (UPF), Barcelona, Spain IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Els Wauters Vesalius Research Center (VRC), VIB, Leuven, Belgium Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium Respiratory Division, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Diether Lambrechts Vesalius Research Center (VRC), VIB, Leuven, Belgium Laboratory for Translational Genetics, Department of Oncology, KU Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Wim Janssens Respiratory Division, University Hospital Gasthuisberg, KU Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Francesca Bigazzi Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy PubMed articlesGoogle scholar articles
  • Gianna Camiciottoli Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy PubMed articlesGoogle scholar articles
  • Michael H Cho Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA Pulmonary and Critical Care Division, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Craig P Hersh Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA Pulmonary and Critical Care Division, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Kathleen Barnes Center for Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Stephen Rennard Division of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA Clinical Discovery Unit, AstraZeneca, Cambridge, UK PubMed articlesGoogle scholar articles
  • Meher Preethi Boorgula Center for Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Jennifer Dy Department of Computer Science, Northeastern University, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Nadia N Hansel Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • James D Crapo Department of Medicine, National Jewish Health, Denver, Colorado, USA PubMed articlesGoogle scholar articles
  • Yohannes Tesfaigzi COPD Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA PubMed articlesGoogle scholar articles
  • Alvar Agusti Respiratory Institute, Hospital Clinic, University of Barcelona, IDIBAPS and CIBERES, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Edwin K Silverman Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA Division of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA PubMed articlesGoogle scholar articles
  • Judith Garcia-Aymerich ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain Universitat Pompeu Fabra (UPF), Barcelona, Spain PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Peter J Castaldi, Channing Division of Network Medicine, 181 Longwood Ave, Boston, MA 02115, USA; peter.castaldi{at}channing.harvard.edu
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Citation

Castaldi PJ, Benet M, Petersen H, et al
Do COPD subtypes really exist? COPD heterogeneity and clustering in 10 independent cohorts

Publication history

  • Received December 10, 2016
  • Revised April 22, 2017
  • Accepted May 8, 2017
  • First published June 21, 2017.
Online issue publication 
October 20, 2017

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