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  • Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB

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Biomarkers of disease
Original article
Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB

Authors

  • Novel N Chegou Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  • Jayne S Sutherland Vaccines and Immunity, Medical Research Council Unit, Fajara, The Gambia PubMed articlesGoogle scholar articles
  • Stephanus Malherbe Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  • Amelia C Crampin Karonga Prevention Study, Chilumba, Malawi PubMed articlesGoogle scholar articles
  • Paul L A M Corstjens Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Annemieke Geluk Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Harriet Mayanja-Kizza Department of Medicine, Makerere University, Kampala, Uganda PubMed articlesGoogle scholar articles
  • Andre G Loxton Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  • Gian van der Spuy Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  • Kim Stanley Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  • Leigh A Kotzé Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  • Marieta van der Vyver Faculty of Health Sciences, School of Medicine, University of Namibia, Windhoek, Namibia PubMed articlesGoogle scholar articles
  • Ida Rosenkrands Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark PubMed articlesGoogle scholar articles
  • Martin Kidd Department of Statistics and Actuarial Sciences, Centre for Statistical Consultation, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  • Paul D van Helden Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  • Hazel M Dockrell Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK PubMed articlesGoogle scholar articles
  • Tom H M Ottenhoff Department of Infectious Diseases, Leiden University Medical Centre, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Stefan H E Kaufmann Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany PubMed articlesGoogle scholar articles
  • Gerhard Walzl Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, Cape Town, South Africa PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Novel N Chegou, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, DST/NRF Centre of Excellence for Biomedical Tuberculosis Research and SAMRC Centre for Tuberculosis Research, Stellenbosch University, P. O. Box 241, Cape Town 8000, South Africa; novel{at}sun.ac.za/novel01{at}gmail.com
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Citation

Chegou NN, Sutherland JS, Malherbe S on behalf of the AE-TBC consortium, et al
Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB
Thorax 2016;71:785-794.

Publication history

  • Received October 30, 2015
  • Revised March 18, 2016
  • Accepted April 11, 2016
  • First published May 4, 2016.
Online issue publication 
August 12, 2016

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