Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

Paul F Mercer; Hannah V Woodcock; Jessica D Eley; Manuela Platé; Michal G Sulikowski; Pascal F Durrenberger; Linda Franklin; Carmel B Nanthakumar; Yim Man; Federica Genovese; Robin J McAnulty; Shuying Yang; Toby M Maher; Andrew G Nicholson; Andy D Blanchard; Richard P Marshall; Pauline T Lukey; Rachel C Chambers

doi:10.1136/thoraxjnl-2015-207429

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Interstitial lung disease

Original article

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

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Paul F Mercer Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles
Hannah V Woodcock Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles
Jessica D Eley Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles
Manuela Platé Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles
Michal G Sulikowski Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles
Pascal F Durrenberger Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles
Linda Franklin Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles
Carmel B Nanthakumar Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
Yim Man Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
Federica Genovese Nordic Bioscience, Herlev, Denmark PubMed articles Google scholar articles
Robin J McAnulty Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles
Shuying Yang Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
Toby M Maher NIHR Respiratory Biomedical Research Unit, Royal Brompton Hospital, London, UK PubMed articles Google scholar articles
Andrew G Nicholson NIHR Respiratory Biomedical Research Unit, Royal Brompton Hospital, London, UK PubMed articles Google scholar articles
Andy D Blanchard Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
Richard P Marshall Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
Pauline T Lukey Department of Fibrosis DPU, Respiratory TA, GlaxoSmithKline, Stevenage, UK PubMed articles Google scholar articles
Rachel C Chambers Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, University College London, London, UK PubMed articles Google scholar articles

Correspondence to Professor Rachel C Chambers, Centre for Inflammation and Tissue Repair, UCL Respiratory, Rayne Institute, 5 University Street, University College London, London WC1E 6JJ, UK; r.chambers{at}ucl.ac.uk

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Citation

Mercer PF, Woodcock HV, Eley JD, et al

Exploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF

Thorax 2016;71:701-711.

Publication history

Received June 15, 2015
Revised March 14, 2016
Accepted March 15, 2016
First published April 21, 2016.

Online issue publication

September 01, 2022

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

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