Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12

Victoria E Jackson; Ioanna Ntalla; Ian Sayers; Richard Morris; Peter Whincup; Juan-Pablo Casas; Antoinette Amuzu; Minkyoung Choi; Caroline Dale; Meena Kumari; Jorgen Engmann; Noor Kalsheker; Sally Chappell; Tamar Guetta-Baranes; Tricia M McKeever; Colin N A Palmer; Roger Tavendale; John W Holloway; Avan A Sayer; Elaine M Dennison; Cyrus Cooper; Mona Bafadhel; Bethan Barker; Chris Brightling; Charlotte E Bolton; Michelle E John; Stuart G Parker; Miriam F Moffat; Andrew J Wardlaw; Martin J Connolly; David J Porteous; Blair H Smith; Sandosh Padmanabhan; Lynne Hocking; Kathleen E Stirrups; Panos Deloukas; David P Strachan; Ian P Hall; Martin D Tobin; Louise V Wain

doi:10.1136/thoraxjnl-2015-207876

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Chronic obstructive pulmonary disease

Original article

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12

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Victoria E Jackson Department of Health Sciences, University of Leicester, Leicester, UK PubMed articles Google scholar articles
Ioanna Ntalla Department of Health Sciences, University of Leicester, Leicester, UK William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK PubMed articles Google scholar articles
Ian Sayers Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK PubMed articles Google scholar articles
Richard Morris School of Social & Community Medicine, University of Bristol, Bristol, UK Department of Primary Care & Population Health, UCL, London, UK PubMed articles Google scholar articles
Peter Whincup Population Health Research Institute, St George's, University of London, London, UK PubMed articles Google scholar articles
Juan-Pablo Casas University College London, Farr Institute of Health Informatics, London, UK Cochrane Heart Group, London, UK PubMed articles Google scholar articles
Antoinette Amuzu Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK PubMed articles Google scholar articles
Minkyoung Choi Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK PubMed articles Google scholar articles
Caroline Dale Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK PubMed articles Google scholar articles
Meena Kumari ISER, University of Essex, Colchester, Essex, UK Department of Epidemiology and Public Health, UCL, London, UK PubMed articles Google scholar articles
Jorgen Engmann Institute of Cardiovascular Science, UCL, London, UK PubMed articles Google scholar articles
Noor Kalsheker School of Life Sciences, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Sally Chappell School of Life Sciences, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Tamar Guetta-Baranes School of Life Sciences, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Tricia M McKeever Division of Epidemiology and Public Health, Nottingham City Hospital, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Colin N A Palmer Cardiovascular and Diabetes Medicine, School of Medicine, University of Dundee, Dundee, UK. PubMed articles Google scholar articles
Roger Tavendale Cardiovascular and Diabetes Medicine, School of Medicine, University of Dundee, Dundee, UK. PubMed articles Google scholar articles
John W Holloway Human Development & Health, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK NIHR Southampton Respiratory Biomedical Research Unit, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK PubMed articles Google scholar articles
Avan A Sayer MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK PubMed articles Google scholar articles
Elaine M Dennison MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK Victoria University, Wellington, New Zealand PubMed articles Google scholar articles
Cyrus Cooper MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton, UK PubMed articles Google scholar articles
Mona Bafadhel Respiratory Medicine Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Bethan Barker Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK National Institute for Health Research Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK PubMed articles Google scholar articles
Chris Brightling Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK National Institute for Health Research Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK PubMed articles Google scholar articles
Charlotte E Bolton Nottingham Respiratory Research Unit, University of Nottingham, City Hospital Campus, Nottingham, UK PubMed articles Google scholar articles
Michelle E John Nottingham Respiratory Research Unit, University of Nottingham, City Hospital Campus, Nottingham, UK PubMed articles Google scholar articles
Stuart G Parker Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Miriam F Moffat Department of Molecular Genetics and Genomics, National Heart and Lung Institute, Imperial College London, London, UK PubMed articles Google scholar articles
Andrew J Wardlaw Institute for Lung Health, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK National Institute for Health Research Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK PubMed articles Google scholar articles
Martin J Connolly Freemasons’ Department of Geriatric Medicine, University of Auckland, New Zealand PubMed articles Google scholar articles
David J Porteous Generation Scotland, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Blair H Smith Division of Population Health Sciences, University of Dundee, Dundee, UK PubMed articles Google scholar articles
Sandosh Padmanabhan Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK PubMed articles Google scholar articles
Lynne Hocking Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK PubMed articles Google scholar articles
Kathleen E Stirrups William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK Department of Haematology, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Panos Deloukas William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia PubMed articles Google scholar articles
David P Strachan Population Health Research Institute, St George's, University of London, London, UK PubMed articles Google scholar articles
Ian P Hall Division of Respiratory Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK PubMed articles Google scholar articles
Martin D Tobin Department of Health Sciences, University of Leicester, Leicester, UK National Institute for Health Research Respiratory Biomedical Research Unit, Glenfield Hospital, Leicester, UK PubMed articles Google scholar articles
Louise V Wain Department of Health Sciences, University of Leicester, Leicester, UK PubMed articles Google scholar articles

Correspondence to Victoria E Jackson, Department of Health Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK; vej3{at}le.ac.uk

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Citation

Jackson VE, Ntalla I, Sayers I, et al

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12

Thorax 2016;71:501-509.

Publication history

Received September 24, 2015
Revised January 5, 2016
Accepted January 29, 2016
First published February 25, 2016.

Online issue publication

May 13, 2016

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