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Original article
The EQ-5D-5L health status questionnaire in COPD: validity, responsiveness and minimum important difference
  1. Claire M Nolan1,2,
  2. Louise Longworth3,
  3. Joanne Lord4,
  4. Jane L Canavan1,
  5. Sarah E Jones1,
  6. Samantha S C Kon1,5,
  7. William D-C Man1,2
  1. 1NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College, Harefield, UK
  2. 2Harefield Pulmonary Rehabilitation Unit, Royal Brompton & Harefield NHS Foundation Trust, London, UK
  3. 3Health Economics Research Group, Brunel University London, London, UK
  4. 4Southampton Health Technology Assessments Centre (SHTAC), University of Southampton, Southampton, UK
  5. 5The Hillingdon Hospitals NHS Foundation Trust, London, UK
  1. Correspondence to Dr William D- C Man Department of Respiratory Medicine, Harefield Hospital, Hill End Road, Harefield UB9 6JH, UK; research{at}williamman.co.uk

Abstract

Background The EQ-5D, a generic health status questionnaire that is widely used in health economic evaluation, was recently expanded to the EQ-5D-5L to address criticisms of unresponsiveness and ceiling effect.

Aims To describe the validity, responsiveness and minimum important difference of the EQ-5D-5L in COPD.

Methods Study 1: The validity of the EQ-5D-5L utility index and visual analogue scale (EQ-VAS) was compared with four established disease-specific health status questionnaires and other measures of disease severity in 616 stable outpatients with COPD. Study 2: The EQ-5D-5L utility index and EQ-VAS were measured in 324 patients with COPD before and after 8 weeks of pulmonary rehabilitation. Distribution and anchor-based approaches were used to estimate the minimum important difference.

Results There were moderate-to-strong correlations between utility index and EQ-VAS with disease-specific questionnaires (Pearson's r=0.47–0.72). A ceiling effect was seen in 7% and 2.6% of utility index and EQ-VAS. Utility index decreased (worsening health status) with indices of worsening disease severity. With rehabilitation, mean (95% CI) changes in utility index and EQ-VAS were 0.065 (0.047 to 0.083) and 8.6 (6.5 to 10.7), respectively, with standardised response means of 0.39 and 0.44. The mean (range) anchor estimates of the minimum important difference for utility index and EQ-VAS were 0.051 (0.037 to 0.063) and 6.9 (6.5 to 8.0), respectively.

Conclusions The EQ-5D-5L is a valid and responsive measure of health status in COPD and may provide useful additional cost-effectiveness data in clinical trials.

  • Pulmonary Rehabilitation
  • Health Economist
  • COPD epidemiology

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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