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Research letter
Does UKLS strategy increase the yield of screen-detected lung cancers? A comparison with ITALUNG
  1. Mario Mascalchi1,
  2. Andrea Lopes Pegna2,
  3. Laura Carrozzi3,
  4. Francesca Carozzi4,
  5. Fabio Falaschi5,
  6. Giulia Picozzi6,
  7. Eugenio Paci7
  1. 1Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy
  2. 2Pneumonology Department, Careggi Hospital, Florence, Italy
  3. 3Cardiopulmonary Department, University Hospital, Pisa, Italy
  4. 4Analytical Cytology and Bio-Molecular Unit, Institute for Oncological Study and Prevention, Florence, Italy
  5. 52nd Radiology Department, University Hospital of Pisa, Pisa, Italy
  6. 6Radiodiagnostic Unit, Institute for Oncological Study and Prevention, Florence, Italy
  7. 7Department of Epidemiology, Institute for Oncological Study and Prevention, Florence, Italy
  1. Correspondence to Professor Mario Mascalchi, “Mario Serio” Department of Experimental and Clinical Biomedical Sciences, University of Florence, Viale Pieraccini, Florence 50133, Italy; m.mascalchi{at}dfc.unifi.it

https://doi.org/10.1136/thoraxjnl-2016-208409

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    The optimal strategy to increase the benefit of low dose computed tomograph (LDCT) screening of lung cancer in terms of as high as possible number of discovered cancers and to reduce the costs, in terms of as low as possible number of LDCT examinations and of interventions on benign lesions, is not established.

    Field and co-workers recently reported1 the results of lung cancer screening with LDCT in the UKLS RCT pilot study that selected eligible subjects with a validated individual risk prediction model, invited potential candidates by mail and applied the Wald Single Screen Design2 with nodule management based on volumetry.1 …

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    Footnotes

    • Contributors MM devised the paper and wrote the paper draft, ALP reviewed the recruitment data and critically discussed the paper. LC critically discussed the risk factors data. FC critically reviewed the manuscript. FF critically discussed the radiological data. GP reviewed radiological data. EP critically revised the paper.

    • Competing interests None declared.

    • Ethics approval Local Ethic Committees of Florence, Pistoia and Pisa Hospitals (approval number 29–30 of 30 September 2003; number 23 of 27 October 2003; and number 00028543 of 13 May 2004.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement The authors intend to share the data from the ITALUNG study concerning recruitment, risk factors of eligible subjects and results of LDCT screening.