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The impact of BCG vaccination on tuberculin skin test responses in children is age dependent: evidence to be considered when screening children for tuberculosis infection
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  • Published on:
    Re:Hypotheses to explain the reduced sensitivity of tuberculin skin test in BCG immunised young children
    • James A. Seddon, Clinical Lecturer
    • Other Contributors:
      • James Paton, Beate Kampmann

    Dear Editor,

    We appreciate the comments by Dr Eisenhut.(1) We did not focus on the sensitivity analysis in our study as we were primarily interested in establishing the impact of BCG on interpretation of tuberculin skin test (TST) responses, which we considered especially relevant in the context of the new NICE guidance.(2) The points raised by Dr Eisenhut are interesting and we agree that the hypotheses put forwa...

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    Conflict of Interest:
    None declared.
  • Published on:
    Hypotheses to explain the reduced sensitivity of tuberculin skin test in BCG immunised young children

    In a recent cohort study investigating tuberculin skin test (TST) in relation to interferon gamma release assay (IGRA) responses in exposed children and relating responses to previous BCG immunisation the authors reported a reduced sensitivity of TST using IGRA as a reference standard at all induration thresholds for young children (less than 5 years old) who had a previous BCG immunisation compared to those who didn't(1...

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    Conflict of Interest:
    None declared.