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The data of Nyilas et al 1 relating nitrogen washout measurements of lung clearance index (LCI) to spirometry in primary ciliary dyskinesia (PCD) are a welcome addition to the current debate.2–5 However, as with the data of Boon et al,4 most of their PCD patients had normal spirometry, so it would be premature to conclude that this relationship holds over the full range of severity of PCD. The suggestion that the relationship may be different in different populations of PCD patients is indeed interesting, and there is considerable genetic variability, as well as management differences across Europe.6 This could be resolved by data sharing across the large European PCD consortia such as BESTCILIA.
Competing interests None declared.
Provenance and peer review Not commissioned; internally peer reviewed.
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