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Correspondence
Further evidence for an association between LCI and FEV1 in patients with PCD
  1. Sylvia Nyilas1,2,
  2. Anne Schlegtendal3,
  3. Sophie Yammine1,2,
  4. Carmen Casaulta2,
  5. Philipp Latzin1,2,
  6. Cordula Koerner-Rettberg3
  1. 1Department of Pediatric Pneumology, University Children's Hospital Basel (UKBB), Basel, Switzerland
  2. 2Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, Bern, Switzerland
  3. 3Department of Pediatric Pneumology, University Children's Hospital of Ruhr University Bochum at St Josef-Hospital, Bochum, Germany
  1. Correspondence to Dr Cordula Koerner-Rettberg, Department of Pediatric Pneumology, University Children's Hospital of Ruhr University Bochum at St Josef-Hospital, Bochum, Germany; Cordula.Koerner-Rettberg@ruhr-uni-bochum.de

https://doi.org/10.1136/thoraxjnl-2015-207206

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    We have taken keen interest in the current discussion on the meaning of the lung clearance index (LCI) in patients with primary ciliary dyskinesia (PCD). In patients with cystic fibrosis (CF), LCI from the nitrogen multiple-breath gas washout (N2-MBW) test has become a sensitive marker for detection of ventilation inhomogeneity with a good correlation between LCI and FEV1.1 However, in patients with PCD, two studies failed to find a correlation for the FEV1 and LCI.1 ,2 This difference in functional measures between CF and PCD was recently challenged by Boon et al,3 showing a robust correlation between LCI and FEV …

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    Footnotes

    • Contributors SN, AS, SY, CC, PL and CK-R: Conceived and designed the experiments. SN, AS and SY: Performed the experiments. SN and AS: Analysed the data. SN and CK-R: Wrote the paper. CK-R: Qualified as the guarantor of the paper, took responsibility for the integrity of the work as a whole, from inception to published article.

    • Funding Fondation Botnar.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Ethics approval Ethics Committee of the Canton of Bern and Ethics Committee of the Ruhr University Bochum.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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