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Author's response: Airway anatomy in COPD: many dimensions to consider
  1. Benjamin M Smith1,2,
  2. Eric A Hoffman3,
  3. R Graham Barr1,4
  1. 1Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
  2. 2Department of Medicine, McGill University, Montreal, Canada
  3. 3Departments of Radiology, Medicine and Biomedical Engineering, University of Iowa, Iowa City, Iowa, USA
  4. 4Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
  1. Correspondence to : Dr Benjamin M Smith, Presbyterian Hospital 9E Room 109, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA; benjamin.m.smith{at}

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We thank Bokov and Delclaux for their thoughtful comments1 on our paper2 and offer the following comments.

The homothety factor, as defined by Bokov and Delclaux,1 describes a structural aspect of the airway tree not directly addressed in our study, which we agree is important and likely also influences airflow in asthma and COPD. However, we believe the suggestion that the two factors, tracheal area and homothety factor, alone characterise the whole bronchial tree omits important structural characteristics, such as …

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  • Contributors BMS contributed to the discussion, formulation, drafting and revising of this correspondence, and is responsible for the overall content as guarantor. EAH contributed to the discussion, formulation and revising of this letter. RGB contributed to the discussion, formulation and revising of this letter.

  • Funding Funding Institutions: U.S. Department of Health and Human Services-National Institutes of Health. Grant Number: HHSN2682009000019C and HHSN268200900020C; HHSN268200900013C, HHSN268200900014C; HHSN268200900015C, HSN268200900016C; HHSN268200900017C, HHSN268200900018C; N01-HC95159-HC95169; R01-HL093081, R01-HL077612, R01-HL075476. Fonds de Recherche du Québec—Santé.

  • Competing nterests: EAH is a founder and shareholder of VIDA Diagnostics, a company that is commercialising pulmonary image analysis software developed, in part, at the University of Iowa.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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