Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study—a randomised controlled trial

Peter A Frith; Philip J Thompson; Rajeev Ratnavadivel; Catherina L Chang; Peter Bremner; Peter Day; Christina Frenzel; Nicol Kurstjens; the Glisten Study Group

doi:10.1136/thoraxjnl-2014-206670

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Chronic obstructive pulmonary disease

Original article

Glycopyrronium once-daily significantly improves lung function and health status when combined with salmeterol/fluticasone in patients with COPD: the GLISTEN study—a randomised controlled trial

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Apr 2015	1084	1228	650
May 2015	2334	543	566
Jun 2015	1213	245	400
Jul 2015	411	151	133
Aug 2015	357	106	98
Sep 2015	230	128	78
Oct 2015	145	67	61
Nov 2015	201	153	94
Dec 2015	105	127	54
Jan 2016	115	79	49
Feb 2016	112	92	49
Mar 2016	96	71	42
Apr 2016	92	78	85
May 2016	94	90	50
Jun 2016	99	77	60
Jul 2016	70	81	56
Aug 2016	98	58	37
Sep 2016	69	50	45
Oct 2016	77	83	55
Nov 2016	82	81	53
Dec 2016	54	76	32
Jan 2017	57	81	28
Feb 2017	20	41	44
Mar 2017	18	84	61
Apr 2017	13	132	49
May 2017	16	88	39
Jun 2017	29	85	35
Jul 2017	89	72	22
Aug 2017	89	76	27
Sep 2017	98	64	32
Oct 2017	111	80	43
Nov 2017	111	76	18
Dec 2017	79	63	22
Jan 2018	268	254	20
Feb 2018	139	103	31
Mar 2018	260	186	32
Apr 2018	168	154	28
May 2018	159	149	20
Jun 2018	119	65	11
Jul 2018	121	79	20
Aug 2018	115	85	19
Sep 2018	135	97	16
Oct 2018	130	114	19
Nov 2018	143	131	21
Dec 2018	217	201	14
Jan 2019	121	89	14
Feb 2019	108	87	29
Mar 2019	83	58	42
Apr 2019	63	45	21
May 2019	63	45	24
Jun 2019	39	29	18
Jul 2019	49	32	19
Aug 2019	35	29	21
Sep 2019	37	21	24
Oct 2019	61	39	16
Nov 2019	66	45	32
Dec 2019	62	44	29
Jan 2020	58	38	22
Feb 2020	103	100	13
Mar 2020	52	35	19
Apr 2020	51	32	30
May 2020	39	25	70
Jun 2020	31	27	12
Jul 2020	29	25	18
Aug 2020	17	15	6
Sep 2020	45	31	12
Oct 2020	56	43	36
Nov 2020	27	23	19
Dec 2020	48	23	16
Jan 2021	47	39	53
Feb 2021	62	26	17
Mar 2021	47	31	23
Apr 2021	36	30	23
May 2021	19	16	8
Jun 2021	26	25	12
Jul 2021	20	20	24
Aug 2021	15	15	10
Sep 2021	30	27	10
Oct 2021	44	38	35
Nov 2021	25	19	26
Dec 2021	27	21	12
Jan 2022	51	44	24
Feb 2022	60	41	12
Mar 2022	88	76	19
Apr 2022	57	40	12
May 2022	61	59	37
Jun 2022	76	70	17
Jul 2022	34	20	9
Aug 2022	53	40	14
Sep 2022	41	38	12
Oct 2022	82	68	17
Nov 2022	36	34	15
Dec 2022	40	34	14
Jan 2023	34	22	9
Feb 2023	49	48	9
Total	12345	8145	4453

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