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Original article
What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK?
  1. Emma L O'Dowd1,
  2. Tricia M McKeever1,
  3. David R Baldwin2,
  4. Sadia Anwar2,
  5. Helen A Powell1,
  6. Jack E Gibson1,
  7. Barbara Iyen-Omofoman2,
  8. Richard B Hubbard1
  1. 1Division of Public Health and Epidemiology, University of Nottingham, Nottingham, UK
  2. 2Department of Respiratory Medicine, Nottingham City Hospital, Nottingham, UK
  1. Correspondence to Dr Emma O'Dowd, Division of Public Health and Epidemiology, University of Nottingham, Room C100, Clinical Sciences Building, Nottingham City Campus, Hucknall Road, Nottingham NG5 1PB, UK; emma.o'dowd@nottingham.ac.uk

Abstract

Background The UK has poor lung cancer survival rates and high early mortality, compared to other countries. We aimed to identify factors associated with early death, and features of primary care that might contribute to late diagnosis.

Methods All cases of lung cancer diagnosed between 2000 and 2013 were extracted from The Health Improvement Network database. Patients who died within 90 days of diagnosis were compared with those who survived longer. Standardised chest X-ray (CXR) and lung cancer rates were calculated for each practice.

Results Of 20 142 people with lung cancer, those who died early consulted with primary care more frequently prediagnosis. Individual factors associated with early death were male sex (OR 1.17; 95% CI 1.10 to 1.24), current smoking (OR 1.43; 95% CI 1.28 to 1.61), increasing age (OR 1.80; 95% CI 1.62 to 1.99 for age ≥80 years compared to 65–69 years), social deprivation (OR 1.16; 95% CI 1.04 to 1.30 for Townsend quintile 5 vs 1) and rural versus urban residence (OR 1.22; 95% CI 1.06 to 1.41). CXR rates varied widely, and the odds of early death were highest in the practices which requested more CXRs. Lung cancer incidence at practice level did not affect early deaths.

Conclusions Patients who die early from lung cancer are interacting with primary care prediagnosis, suggesting potentially missed opportunities to identify them earlier. A general increase in CXR requests may not improve survival; rather, a more timely and appropriate targeting of this investigation using risk assessment tools needs further assessment.

  • Lung Cancer
  • Clinical Epidemiology

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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