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It not your genes but how you wear them in IPF that's important
The genes you own are determined at birth but their expression, and the proteins that they make, can change over time. These epigenetic changes are thought to be responsible for a number of diseases associated with aging. In this issue of Thorax Korfei and colleagues describe how changes in key molecules associated with gene expression, the HDAC family, lead to cellular features associated with fibrosis in both epithelial cells and fibroblasts, providing evidence to pursue investigation targeting this family of molecules as a potential therapy for IPF (see page 1022). May be it really is time to try a new style of genes?
After all that, lung cancer really is all in the genes?
30 years ago Professor Geoffrey Rose famously wrote in his essay Sick Individuals and Sick Populations that ‘if everybody smoked 20 cigarettes a day then lung cancer would be a genetic disease’. It turns out he was both right and wrong. In a new epidemiological study using US registry data of over 5500 lung cancer cases assessing the genetic contribution to lung cancer Carr and …
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