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Rhinovirus-induced interferon production in asthma
  1. Simonetta Baraldo1,
  2. Marina Saetta1,
  3. Angelo Barbato2,
  4. Marco Contoli3,
  5. Alberto Papi3
  1. 1 Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy
  2. 2 Department of Woman and Child Health, University of Padova, Padova, Italy
  3. 3 Department of Medical Sciences, University of Ferrara, Ferrara, Italy
  1. Correspondence to Dr Simonetta Baraldo, Department of Cardiological, Thoracic and Vascular Sciences Respiratory Diseases Clinic, University of Padova, Via Giustiniani 3, Padova 35128, Italy; simonetta.baraldo{at}

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After reading the article by Sykes et al,1 we would like to comment on impaired response to rhinovirus in relation to asthma severity. The authors examined rhinovirus-induced interferon (IFN) production in a cohort of asthmatic patients compared with controls. While they previously reported in this population a reduced IFN production in cells from bronchoalveolar lavage,2 they fail to document such an impaired response in bronchial epithelial cells.1 …

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  • Contributors SB, MS, AB, MC and AP conceived and drafted this manuscript.

  • Funding Work supported by the Universities of Padova and Ferrara and the Italian Society of Pediatric Respiratory Diseases.

  • Competing interests None.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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