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  • Authors’ response: Epithelial-mesenchymal Transition (EMT) is a common molecular programme in epithelial cells which can be triggered by injury

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Correspondence
Authors’ response: Epithelial-mesenchymal Transition (EMT) is a common molecular programme in epithelial cells which can be triggered by injury
  1. Domokos Bartis,
  2. David R Thickett
  1. Department of Clinical Respiratory Sciences, Centre for Translational Inflammation and Fibrosis Research, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
  1. Correspondence to Dr Domokos Bartis, Department of Clinical Respiratory Sciences, Centre for Translational Inflammation and Fibrosis Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham B15 2WB, UK; d.bartis{at}outlook.com

https://doi.org/10.1136/thoraxjnl-2014-205647

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    We thank Sohal et al 1 for commenting on our recent paper.2 The authors argue in their commentary that morphological/histological signs of epithelial-mesenchymal transition (EMT) in patients’ samples, for example, reticular basement membrane fragmentation, are more relevant in detecting EMT than looking for typical EMT-associated molecular patterns in the first place.

    EMT is defined as the gradual differentiation of epithelial cells into mesenchymal cells involving intermediate phenotypes. Different types of EMT seem to be quite universally present in organ development …

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    Footnotes

    • Contributors DB and DRT wrote the manuscript.

    • Funding European Commission, FP7-PEOPLE-IEF 300371; European Respiratory Society ERS-LTRF 2011-131.

    • Competing interests None.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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