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Exacerbations in non-COPD patients: recognition?
  1. Gavin C Donaldson
  1. Correspondence to Dr G C Donaldson, Airway Disease Section, National Heart and Lung Institute, Emmanuel Kaye Building, Manresa Road, London SW3 6LR, UK; gavin.donaldson{at}

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COPD is a progressive lung disease that leads to significant impairment of quality of life and is the third leading cause of death worldwide.1 It is principally caused by tobacco smoking over many years through airway inflammation and oxidative stress to lung tissue. Patients exposed to smoke or occupational dusts are diagnosed with the disease when their post-bronchodilator FEV1/FVC ratio falls to <0.7.2 Disease severity is assessed differently by expressing the measured FEV1 as a percentage of the expected value for normal, healthy people of similar sex, age and height. The threshold value of <0.7 for the FEV1/FVC ratio is arbitrary and may not always identify people in the early stages of COPD with smoking-related lung damage.

COPD exacerbations (the flare-up of respiratory symptoms) are often triggered by viral or bacterial infection and cause patients sometimes to seek medical help. Attention has focused on those patients most susceptible to exacerbation as the disease appears to progress more rapidly in this group, and consequently, they form a high proportion of the group with most severe disease irrespective of the outcome measure.3 ,4 However, studies show that exacerbations occur even in patients with the least severe COPD.5

The study by Tan and colleagues6 examined respiratory symptoms in those with and without COPD. They found half the rate of ‘exacerbation-like’ events in non-COPD patients compared with patients with COPD. In the former, health-related quality of life was poorer with social and physical activity reduced compared with those with no events. The exacerbation-like events in non-COPD patients were more frequent in women, those who were wheezing or using respiratory drugs and in poor health, though no association was seen with chronic cough or chronic sputum production. A key strength of the study was that subjects were selected by established criteria to achieve a representative sample of the general population, and the overall participation rate of 74% was good. There were two important limitations—namely, patients with undetected asthma, COPD, or emphysema could not be excluded and there is a risk of bias in that individuals with respiratory symptoms might be more eager to participate in such a study.

There is no logical reason why an acute episode of respiratory symptoms cannot occur in people without COPD. Indeed, very few of us have not taken time off work, put off social engagements and stayed indoors because of a respiratory infection—for example, a common cold. We experienced symptoms of nasal congestion, coughing and, occasionally, brought up sputum. These episodes may not be called exacerbations but are similar in most respects, apart possibly from breathlessness, as sufficient reserves remain in the respiratory system. These events do not receive much medical attention as few normally healthy people would or should seek professional healthcare. They are not, however, ignored by the pharmaceutical industry, which profits by selling over-the-counter anti-tussive drugs, expectorants, mucolytic agents and anti-histamine decongestants to people who self-medicate. One reason why we might not seek medical attention for these episodes is that we have experienced them since birth and always recovered. This acceptance of respiratory infection might explain why people are admitted to hospital with an acute COPD exacerbation but have not previously been diagnosed with the disease.7

The finding that episodes of respiratory symptoms can occur in non-COPD (healthy) individuals does not imply that they will have COPD. There is a danger that elderly but normal people will in the aftermath, especially if their FEV1/FVC ratio has dipped below the threshold, be prescribed respiratory drugs—possibly for the rest of their lives if follow-up is poor. As long as respiratory viruses and pathogenic bacteria circulate in the community these respiratory episodes are normal events. However, sometimes exacerbations cause lasting damage to the respiratory system. In patients with COPD, only in about 7.1% of exacerbations did the peak expiratory flow clearly not recover to pre-exacerbation levels.8 In childhood, respiratory infections impair lung development.9 More long-term research is needed to identify the cause of these events as these infections might also occur in the healthy adult population.

Opportunities for early diagnosis of COPD should not be missed.10 It has been known for some time, for example, that chronic mucus hypersecretion is associated with excess FEV1 decline in the general population.11 There are no treatments that can reliably reduce disease progression apart from smoking cessation and perhaps, increasing physical activity,12 but these need to be started early. Patients who meet the spirometric criteria for COPD may already have had a considerable and irreversible loss of small airways and lung function. A warning about respiratory symptoms in middle-age, possibly bronchitis or breathlessness on mild exertion, may be the public health warning catch-phrase that is needed to alert those at risk. Such a warning might prompt the millions with undetected disease13 to seek treatment. However, the evidence about which symptoms and signs best identify the onset of COPD is lacking and consequently, longitudinal follow-up of cohorts with respiratory symptoms with normal or mild airflow limitation is required.



  • Competing interests None.

  • Provenance and peer review Commissioned; internally peer reviewed.

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