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Journal club
Ambrisentan for pulmonary fibrosis
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  1. Ravi Punwani
  1. Correspondence to Dr Ravi Punwani, The Royal Marsden NHS Foundation Trust, Down's Road, Sutton, Surrey SM2 5PT, UK; ravi.punwani{at}rmh.nhs.uk

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This randomised, double-blind, placebo-controlled study is one of the largest multicentre studies investigating whether ambrisentan (an endothelin A receptor antagonist) reduces the rate of idiopathic pulmonary fibrosis (IPF) progression.

The investigators compared ambrisentan (more commonly used in the treatment of pulmonary hypertension (PH)) with placebo on the basis of preclinical studies suggesting endothelin …

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