Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema

Peter J Castaldi; Jennifer Dy; James Ross; Yale Chang; George R Washko; Douglas Curran-Everett; Andre Williams; David A Lynch; Barry J Make; James D Crapo; Russ P Bowler; Elizabeth A Regan; John E Hokanson; Greg L Kinney; Meilan K Han; Xavier Soler; Joseph W Ramsdell; R Graham Barr; Marilyn Foreman; Edwin van Beek; Richard Casaburi; Gerald J Criner; Sharon M Lutz; Steven I Rennard; Stephanie Santorico; Frank C Sciurba; Dawn L DeMeo; Craig P Hersh; Edwin K Silverman; Michael H Cho

doi:10.1136/thoraxjnl-2013-203601

Article info

PDF

PDF +
Supplementary
Material

Chronic obstructive pulmonary disease

Original article

Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema

Free

Authors

Peter J Castaldi Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA Divison of General Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Jennifer Dy Department of Computer Science, Northeastern University, Boston, Massachusetts, USA PubMed articles Google scholar articles
James Ross Surgical Planning Laboratory and Laboratory of Mathematics in Imaging, Brigham and Women's Hospital, Boston, Massachusetts, USA PubMed articles Google scholar articles
Yale Chang Department of Computer Science, Northeastern University, Boston, Massachusetts, USA PubMed articles Google scholar articles
George R Washko Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles
Douglas Curran-Everett Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, Massachusetts, USA PubMed articles Google scholar articles
Andre Williams Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, Massachusetts, USA PubMed articles Google scholar articles
David A Lynch Department of Radiology, National Jewish Health, Denver, Massachusetts, USA PubMed articles Google scholar articles
Barry J Make Department of Medicine, National Jewish Health, Denver, Massachusetts, USA PubMed articles Google scholar articles
James D Crapo Department of Medicine, National Jewish Health, Denver, Massachusetts, USA PubMed articles Google scholar articles
Russ P Bowler Department of Medicine, National Jewish Health, Denver, Massachusetts, USA PubMed articles Google scholar articles
Elizabeth A Regan Department of Medicine, National Jewish Health, Denver, Massachusetts, USA PubMed articles Google scholar articles
John E Hokanson Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado, USA PubMed articles Google scholar articles
Greg L Kinney Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado, USA PubMed articles Google scholar articles
Meilan K Han Department of Internal Medicine, Division of Pulmonary and Critical Care, University of Michigan Health System, Ann Arbor, Michigan, USA PubMed articles Google scholar articles
Xavier Soler Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, USA PubMed articles Google scholar articles
Joseph W Ramsdell Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, USA PubMed articles Google scholar articles
R Graham Barr Departments of Medicine and Epidemiology, Columbia University Medical Center, New York, USA PubMed articles Google scholar articles
Marilyn Foreman Morehouse School of Medicine, Atlanta, USA PubMed articles Google scholar articles
Edwin van Beek Clinical Research Imaging Centre, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Richard Casaburi Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA PubMed articles Google scholar articles
Gerald J Criner Temple University, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Sharon M Lutz Department of Biostatistics, University of Colorado, Denver, USA PubMed articles Google scholar articles
Steven I Rennard Anschutz Medical Campus, Aurora, USA University of Nebraska Medical Center, Omaha, USA PubMed articles Google scholar articles
Stephanie Santorico Department of Mathematics and Statistical Sciences, University of Colorado, Denver, USA PubMed articles Google scholar articles
Frank C Sciurba Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, USA PubMed articles Google scholar articles
Dawn L DeMeo Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles
Craig P Hersh Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles
Edwin K Silverman Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles
Michael H Cho Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articles Google scholar articles

Correspondence to Dr Peter Castaldi, Channing Division of Network Medicine, Brigham and Women's Hospital, 181 Longwood Ave., Boston, MA 02115, USA; peter.castaldi{at}channing.harvard.edu

View Full Text

Citation

Castaldi PJ, Dy J, Ross J, et al

Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema

Thorax 2014;69:416-423.

Publication history

Received March 19, 2013
Revised January 17, 2014
Accepted January 22, 2014
First published February 21, 2014.

Online issue publication

April 12, 2014

Article Versions

Previous version (21 February 2014).
You are viewing the most recent version of this article.

Supplementary Data

This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

Files in this Data Supplement:

Data supplement 1 - Online supplement

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Article Versions

Supplementary Data

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password