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SKUP3 trial: comment
  1. John Stradling1,
  2. Malcolm Kohler2
  1. 1 Oxford Centre for Respiratory Medicine, Oxford University, Churchill Hospital Campus, Oxford, UK
  2. 2 Division of Pulmonology, University Hospital Zurich, Zurich, Switzerland
  1. Correspondence to Professor J Stradling, Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford OX3 7LJ, UK; john.stradling{at}

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The paper on uvulopalatopharyngoplasty (the SKUP3 trial, September 2013 issue of Thorax) is a significant contribution to the literature on the surgical management of obstructive sleep apnea (OSA).1 The authors are to be congratulated on pushing through such a difficult trial with good control subjects. However, there is one concern that we have, which may alter the clinical conclusions that should be drawn. Patients for this trial were highly selected. In particular, none had had a previous tonsillectomy, and Friedman stage III (ie, only small tonsils) were specifically excluded. The Friedman stage I and II patients entered into this study had large tonsils by definition or, when there were only small tonsils, the tongue was low (suggesting they might still be important). Thus this study was very much one of tonsillar resection with an added, and limited, palatal resection. Therefore we do not know which bit of the operation contributed most to the fall in apnea-hypopnea index (AHI). The authors imply from their study and from previous data that, because tonsillar size did not predict degree of surgical benefit, the tonsillar resection contribution to outcome was likely to be limited. However, this argument is possibly flawed. Tonsillar enlargement is known to be important,2 and patients with OSA will present with symptoms when the tonsils reach whatever is the critical size in that patient to cause obstruction, and this size is likely to depend on underlying pharyngeal dimensions (as it does in children3). Thus their removal, whatever the critical size reached, will help relieve OSA. We would be reluctant, based on this study, to ascribe surgical success to the palatal resection component (perhaps implied by the article's title) and wonder if the success results more from the tonsillectomy, as is the case in children.4 This trial should not be used as evidence to support palatal resection in OSA, especially given that this operation adversely influences the future use of continuous positive airway pressure (CPAP), should this be required.5


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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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