Dr Young and Ms Hopkins1 suggest that the lack of a confirmation of the ‘Hispanic paradox’ for lung phenotypes in the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study could be due to differences in the distribution of Hispanic subgroups and lower smoking exposure in MESA compared to the study by Bruse et al. 2 As suggested, we repeated our analyses stratifying the Hispanic group into those of Mexican and non-Mexican origin and found similar results to initial findings. In a sensitivity analysis including only those Hispanic-Americans who identified Mexico as their country of origin, we again found that among both women and men, genetic ancestry did …