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Correspondence
Author's response: heterogeneity of change in LCI in patients with cystic fibrosis following antibiotic treatment
  1. Alex Horsley1,2
  1. 1 Institute of Inflammation and Repair, University of Manchester, Manchester, UK
  2. 2 Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester, Manchester, UK
  1. Correspondence to Dr Alex Horsley, Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester, Manchester, M239LT, UK; alexander.horsley{at}manchester.ac.uk

https://doi.org/10.1136/thoraxjnl-2013-204359

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    I thank Yammine et al for their comments1 on our paper.2 In their interesting study, Yammine et al 1 have noted similar findings to those we described,2 albeit in a less severely affected and younger population of cystic fibrosis (CF) patients. This raises important questions about what is happening in the lungs of CF patients during treatment for an exacerbation as well as the utility of lung clearance index (LCI) in this setting. It would appear that forced expiratory volume in 1 s (FEV1) is the more sensitive marker for change in this circumstance across a wide range of disease severities. Certainly the change in …

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    Footnotes

    • Funding AH is funded by a National Institute for Health Research Clinician Scientist award. The views expressed are those of the author and not necessarily those of the NHS, the NIHR or the Department of Health.

    • Disclaimer The views expressed are those of the author, and do not necessarily represent those of co-authors on the original study.

    • Competing interests None.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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