You are here

Article Text

Article menu
PostScript
Correspondence
Reasons for heterogeneous change in LCI in children with cystic fibrosis after antibiotic treatment
Free
  1. Sophie Yammine1,2,
  2. Anja Bigler1,
  3. Carmen Casaulta1,
  4. Florian Singer1,3,
  5. Philipp Latzin1,2
  1. 1Division of Respiratory Medicine, Department of Pediatrics, University Children's Hospital of Bern, Bern, Switzerland
  2. 2University Children's Hospital of Basel UKBB, Basel, Switzerland
  3. 3University Children's Hospital of Zurich, Zurich, Switzerland
  1. Correspondence to Professor Philipp Latzin, University Children's Hospital UKBB, Spitalstrasse 33, Postfach, Basel 4031, Switzerland; philipp.latzin{at}ukbb.ch

https://doi.org/10.1136/thoraxjnl-2013-204283

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    With great interest we read the paper of Horsley et al.1 In their prospective observational study they showed significant improvement in indices of ventilation capacity (spirometry) and ventilation heterogeneity (multiple-breath washout (MBW)) after a course of intravenous antibiotics in subjects with cystic fibrosis (CF). There was considerable heterogeneity of lung clearance index (LCI) response as observed previously.2 Here we aim to disentangle underlying physiological mechanisms of this heterogeneous response.

    We assessed changes of lung function parameters before and after 23 courses of intravenous antibiotics in 19 children with CF aged 5–18 years. Children performed arterial blood oxygen measurement, nitrogen MBW,3 , …

    View Full Text

    Supplementary materials

    • Supplementary Data

      This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

      Files in this Data Supplement:

    Linked Articles