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Community-based recruitment of patients with COPD into clinical research
  1. Simon E Brill1,
  2. Ethaar El-Emir1,
  3. James P Allinson1,
  4. Gavin C Donaldson1,
  5. Irwin Nazareth2,
  6. Jadwiga A Wedzicha1
  1. 1Centre for Respiratory Medicine, University College London Medical School, London, UK
  2. 2Department of Primary Care & Population Health, University College London Medical School, London, UK
  1. Correspondence to : Dr Simon E Brill, Centre for Respiratory Medicine, University College London Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK; simon.brill{at}


Abstract Identifying subjects for clinical trials is difficult and the evidence base for recruitment strategies is limited, particularly in the field of COPD. We compared the efficiency and patient characteristics of different community-based recruitment strategies during a non-commercial COPD trial in the UK. Recruiting from general practice COPD registers was less efficient and identified patients with significantly milder disease than recruiting through pulmonary rehabilitation and patient groups. We report our experience and propose that pulmonary rehabilitation and patient groups may represent an enriched pool of COPD patients to recruit into clinical trials.

Trial registration number: EudraCT 2011-001063-43

  • COPD Epidemiology
  • Pulmonary Rehabilitation

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